GITR Antibody (YA1333)
(Synonyms: AITR; GITR; TNFRSF18; CD357)GITR Antibody (YA1333) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GITR.
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Host:
Rabbit
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Isotype:
IgG
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Application:
FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:50-1:100 | 1:10000 |
Product Details
GITR Antibody (YA1333) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GITR.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 26 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 26 kDa
Recombinant human GITR protein
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Glucocorticoid-induced TNF receptor family-associated protein (GITR) is a co-stimulatory cell surface receptor belonging to the TNFR superfamily (TNFRSF). GITR is expressed on regulatory T cells (Tregs) and some activated immune cells, including effector cells. GITR mediates NF-κB activation through the TRAF2/NIK pathway.
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Secreted
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Expression
Tissue_specificity:It is expressed in lymph nodes and peripheral blood leukocytes, but its expression is weaker in the spleen.
Induction:Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation -
Isoforms & Post-Translational Modification
GITR has 3 isomers: Q9Y5U5-1: 26000 Da (predicted); Q9Y5U5-2: 26827 Da (predicted); Q9Y5U5-3: 25110 Da (predicted).
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Subunit
Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA
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SwissProt ID
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Synonyms
AITR; GITR; TNFRSF18; CD357
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Research Field
Signal Transduction
Documentation
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