Kuwanon G
Based on 1 publication(s) in Google Scholar
Kuwanon G is a flavonoid compound and an antagonist of the bombesin receptor. Kuwanon G has multiple activities such as bactericidal, anti-tumor, anti-inflammatory, antioxidant, anti-atherosclerotic, and neuroprotective effects. Kuwanon G exhibits strong antibacterial activity against oral pathogens, especially cariogenic bacteria and periodontal pathogens. Kuwanon G can induce apoptosis and inhibit proliferation, migration, and invasion of tumor cells. Kuwanon G can be used in the research of diseases such as gastric cancer and atherosclerosis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.45%
- CAS 番号: 75629-19-5
- 分子式: C40H36O11
- 分子量:692.71
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保管条件:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-N2600
Kuwanon HBombesin Receptor Antagonist/Platelet Activation Inhibitor/GRPR Antagonist -
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Kukoamine BActive Compound -
HY-N4247R
Kuwanon G (Standard)Standard of Kuwanon G -
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KenpaulloneCDK1/GSK-3β Inhibitor
MedChemExpress（MCE）の使用を引用している文献 Kuwanon G
More
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Platelet | IC50 |
13.2 x 10-5 M
Compound: kumanon G
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Inhibition of thromboxane B2 formation in Wistar King platelets
Inhibition of thromboxane B2 formation in Wistar King platelets
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[PMID: 3097265] |
| Platelet | IC50 |
8.93 x 10-5 M
Compound: kumanon G
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Inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid formation in Wistar King platelets
Inhibition of 12-hydroxy-5,8,10-heptadecatrienoic acid formation in Wistar King platelets
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[PMID: 3097265] |
体外実験
Kuwanon G (5-70 μM; 48 h) can inhibit the apoptosis of HT22 cells induced by Advanced glycation end products (HY-NP165) and the elevation of MDA and ROS levels, and restore the intracellular Ach level. The mechanism involves the PI3K/Akt/GSK3αβ signaling pathway[1].
Kuwanon G (0-20 μg/mL; 0-10 min) has an MIC of 8.0 μg/mL for Streptococcus mutans[2].
Kuwanon G (0-160 μM; 1-24 h) can inhibit the proliferation, migration and invasion, promote cell apoptosis, and inhibit the expression of MMP2 and MMP9 in gastric cancer cells. The mechanism involves the inhibition of the PI3K/AKT/mTOR pathway[3].
Kuwanon G (2-20 μM; 24 h) can inhibit lipid accumulation and the mRNA levels of inflammatory factors in RAW 264.7 cells treated with ox-LDL (HY-NP135). The mechanism involves the activation of the LXRα-ABCA1/ABCG1 pathway and the inhibition of NF-κB[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC 803, HGC 27, AGS and SGC-7901 cells
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Concentration:0, 1.25, 5, 10, 20, 40, 80 and 160 μM
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Incubation Time:24 h
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Result:Inhibited the proliferation of gastric cancer cells in a concentration-dependent manner.
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Cell Line:RAW264.7 cells treated ox-LDL (HY-NP135)
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Concentration:20 μM
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Incubation Time:24 h
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Result:Increased the levels of ABCA1, ABCG1 and LXRα.
体内実験
Kuwanon G (5 mg/kg; intraperitoneal injection; once every other day; 16 weeks) has an ameliorative effect in the atherosclerotic mouse model of ApoE-/- fed a high-fat diet[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male ApoE-deficient (ApoE-/-) mice treated high-fat diet[4]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; once every other day; 16 weeks
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Result:Remarkably reduced the atherosclerotic lesion areas and macrophage content.
Reduced hyperlipidemia and serum inflammatory cytokines in vivo.
化学情報
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CAS 番号 75629-19-5
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性状 Solid
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分子量 692.71
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分子式 C40H36O11
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Color Light yellow to yellow
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SMILES
O=C1C(C/C=C(C)\C)=C(C2=CC=C(O)C=C2O)OC3=C([C@H]4C=C(C)C[C@@H](C5=CC=C(O)C=C5O)[C@@H]4C(C6=CC=C(O)C=C6O)=O)C(O)=CC(O)=C13
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別名
クワノンG
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (72.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (282 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Gan WJ, et al. Kuwanon G protects HT22 cells from advanced glycation end product-induced damage. Exp Ther Med. 2021 May;21(5):425. [Content Brief]
[2]. Park KM, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol. 2003 Feb;84(2-3):181-5. [Content Brief]
[3]. Geng Z, et al. [Kuwanon G inhibits growth, migration and invasion of gastric cancer cells by regulating the PI3K/AKT/mTOR pathway]. Nan Fang Yi Ke Da Xue Xue Bao. 2024 Aug 20;44(8):1476-1484. [Content Brief]
[4]. Liu XX, et al. Kuwanon G attenuates atherosclerosis by upregulation of LXRα-ABCA1/ABCG1 and inhibition of NFκB activity in macrophages. Toxicol Appl Pharmacol. 2018 Feb 15;341:56-63. [Content Brief]
[5]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4436 mL | 7.2180 mL | 14.4361 mL | 36.0901 mL |
| 5 mM | 0.2887 mL | 1.4436 mL | 2.8872 mL | 7.2180 mL | |
| 10 mM | 0.1444 mL | 0.7218 mL | 1.4436 mL | 3.6090 mL | |
| 15 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4060 mL | |
| 20 mM | 0.0722 mL | 0.3609 mL | 0.7218 mL | 1.8045 mL | |
| 25 mM | 0.0577 mL | 0.2887 mL | 0.5774 mL | 1.4436 mL | |
| 30 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.2030 mL | |
| 40 mM | 0.0361 mL | 0.1805 mL | 0.3609 mL | 0.9023 mL | |
| 50 mM | 0.0289 mL | 0.1444 mL | 0.2887 mL | 0.7218 mL | |
| 60 mM | 0.0241 mL | 0.1203 mL | 0.2406 mL | 0.6015 mL |
Kuwanon G 関連分類
HY-N4247 関連分類
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