Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry
- Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9. doi: 10.1006/bbrc.1995.2173.
Affiliations
- 1. Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
PMID: 7646517
DOI: 10.1006/bbrc.1995.2173
Abstract
Kuwanon G and H, isolated from the methanol extract of Morus bombycis, inhibited specific binding of [125I]gastrin-releasing peptide (GRP) to GRP-preferring receptors in murine Swiss 3T3 fibroblasts with Ki values of 470 and 290 nM, respectively. Kuwanon H was one order of magnitude less potent for inhibiting [125I]bombesin binding to neuromedin B (NMB)-preferring receptors in rat esophagus membranes. This compound antagonized bombesin-induced increases in the cytosolic free calcium concentration and GRP-induced DNA synthesis in Swiss 3T3 cells. Thus, kuwanon H, and possibly kuwanon G also, are specific antagonists for the GRP-preferring receptor and can be useful for studying the physiological and pathological role of GRP.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Bombesin Receptor; Bacterial; Apoptosis; Reactive Oxygen Species (ROS); PI3K; Akt; GSK-3; MMP; mTOR; NF-κB; LXRResearch Areas: Neurological Disease; Inflammation/Immunology; Infection; Cardiovascular Disease; Cancer
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target: Bombesin ReceptorResearch Areas: Cancer
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Research Areas: Cancer
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target: Reference Standards; Bombesin Receptor; Bacterial; Apoptosis; Reactive Oxygen Species (ROS); PI3K; Akt; GSK-3; MMP; mTOR; NF-κB; LXRResearch Areas: Neurological Disease; Inflammation/Immunology; Infection; Cardiovascular Disease; Cancer