Indatuximab ravtansine
Based on 1 publication(s) in Google Scholar
Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) based on a murine/human chimeric form of B-B4 (specific for CD138), linked to the maytansinoid agent DM4 by disulphide bonds. Indatuximab ravtansine shows anti-tumor activities.
For research use only. We do not sell to patients.
- Purity : 95.78%
- CAS No.: 1238517-16-2
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Indatuximab ravtansine
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Biological Activity
Description
In Vitro
Indatuximab ravtansine (1 pM-100 nM; 5 days) shows cytotoxic effects in RPMI 8226, MOLP-8 and U266 cell lines (significant CD138 expression), with IC50 values of 200 pM, 40 pM, and 20 pM for RPMI 8226, MOLP-8, and U266 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RPMI 8226, MOLP-8 and U266 cell lines
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Concentration:1 pM-100 nM
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Incubation Time:5 days
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Result:Showed cytotoxic effects in RPMI 8226, MOLP-8 and U266 cell lines.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice inoculated with MOLP-8 multiple myeloma xenografts[1]
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Dosage:5.3 mg/kg, 10.6 mg/kg or 21.2 mg/kg
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Administration:i.v.; once
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Result:Inhibited multiple myeloma tumour growth in vivo and improved host survival.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1238517-16-2
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Indatuximab ravtansine]
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Synonyms
BT-062; nBT062-DM4
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indatuximab ravtansine Related Classifications
HY-141607 Related Classifications
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