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AB-680 ammonium

23 Cited Publications
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Based on 23 publication(s) in Google Scholar

AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

For research use only. We do not sell to patients.

  • Formula: C20H30ClFN6O9P2
  • Molecular Weight:614.89
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • AB-680 ammonium Chemical Structure
    AB-680 ammonium Chemical Structure
  • Experimental Validation Results for AB-680 ammonium
  • Experimental Validation Results for AB-680 ammonium
  • Experimental Validation Results for AB-680 ammonium
  • Experimental Validation Results for AB-680 ammonium
  • Experimental Validation Results for AB-680 ammonium
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Publications Citing Use of MedChemExpress (MCE) AB-680 ammonium

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ELISABio/Physico-chemical AssayIn Vivo Efficacy StudyHistological Imaging/StainingIHC
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  • Bio/Physico-chemical Assay
  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • IHC
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  • AB-680 ammonium Chemical Structure
    AB-680 ammonium Chemical Structure
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    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Feb 17;85(4):692-703. [Abstract]

    Customer Validation
     IFNγ levels measured by ELISA in supernatant of NY-ESO/624mel cultures exposed to AMP (300 μmol/L) with or without AB-680 (0.5 μmol/L) for 24 hous.

  • 1/16

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Feb 17;85(4):692-703. [Abstract]

    Customer Validation
     Percentage of labeled (M + 5) ADO and AMP out of total intracellular adenosine (ADO) in activated (1 ng/mL αCD3) NY-ESO-1–specific T cells exposed to isotopically labeled 15N5-AMP for 3 hours in presence or not of either AB-680 (0.5 μmol/L).

  • 1/16

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498. [Abstract]

    Customer Validation
     Image, volumes, and weights of the AB-680 (20 mg/kg; i.p.; once weekly for 3 weeks)‐treated versus Control KPC subcutaneous allografts (n = 6 samples per group).

  • 1/16

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498. [Abstract]

    Customer Validation
     Representative images of H&E staining, Masson's trichrome staining (MTS), and immunohistochemistry staining of CD8, Granzyme B, α‐SMA. Scale bar: 200 µm. The results showed that AB-680 (20 mg/kg; i.p.; once weekly for 3 weeks) significantly increased the numbers of CD8+ and Granzyme B+ cells.

  • 1/16

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498. [Abstract]

    Customer Validation
     Representative images of immunohistochemistry staining of CXCL5 and CXCR2 in the KPC tumors from the indicated treatment groups. The results showed that AB-680 (20 mg/kg, i.p.; once weekly) also increased the percentage of the corresponding receptor CXCR2+ area in treated tumors.

  • AB-680 ammonium