2. Immunology/Inflammation
  3. CD73
  4. AB-680 ammonium

AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

For research use only. We do not sell to patients.

AB-680 ammonium Chemical Structure

AB-680 ammonium Chemical Structure

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AB-680 ammonium Related Antibodies

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Description

AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

IC50 & Target

Ki: 4.9 pM (hCD73)[1]
In Vitro

AB-680 ammonium inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AB-680 ammonium Related Antibodies
Clinical Trial
Molecular Weight

614.89

Formula

C20H30ClFN6O9P2
SMILES

O=P(CP(O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1.[NH4+].[NH4+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AB-680 ammonium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AB-680AB680AB 680CD73ecto-5′-nucleotidase, NT5Epotentreversible. selective. ecto-nucleotidaseecto-nucleotidasesCD39. anti-tumorInhibitorinhibitorinhibit

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AB-680 ammonium
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