2. Immunology/Inflammation
  3. CD73
  4. AB-680 ammonium

AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

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AB-680 ammonium Related Antibodies

Top Publications Citing Use of Products

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Feb 17;85(4):692-703.  [Abstract]

    IFNγ levels measured by ELISA in supernatant of NY-ESO/624mel cultures exposed to AMP (300 μmol/L) with or without AB-680 (0.5 μmol/L) for 24 hous.

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Cancer Res. 2025 Feb 17;85(4):692-703.  [Abstract]

    Percentage of labeled (M + 5) ADO and AMP out of total intracellular adenosine (ADO) in activated (1 ng/mL αCD3) NY-ESO-1–specific T cells exposed to isotopically labeled 15N5-AMP for 3 hours in presence or not of either AB-680 (0.5 μmol/L).

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498.  [Abstract]

    Image, volumes, and weights of the AB-680 (20 mg/kg; i.p.; once weekly for 3 weeks)‐treated versus Control KPC subcutaneous allografts (n = 6 samples per group).

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498.  [Abstract]

    Representative images of H&E staining, Masson's trichrome staining (MTS), and immunohistochemistry staining of CD8, Granzyme B, α‐SMA. Scale bar: 200 µm. The results showed that AB-680 (20 mg/kg; i.p.; once weekly for 3 weeks) significantly increased the numbers of CD8+ and Granzyme B+ cells.

    AB-680 ammonium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 Nov;10(33):e2302498.  [Abstract]

    Representative images of immunohistochemistry staining of CXCL5 and CXCR2 in the KPC tumors from the indicated treatment groups. The results showed that AB-680 (20 mg/kg, i.p.; once weekly) also increased the percentage of the corresponding receptor CXCR2+ area in treated tumors.

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    Description

    AB-680 ammonium is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

    IC50 & Target

    Ki: 4.9 pM (hCD73)[1]
    In Vitro

    AB-680 ammonium inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    AB-680 ammonium Related Antibodies
    Molecular Weight

    614.89

    Formula

    C20H30ClFN6O9P2
    SMILES

    O=P(CP(O)([O-])=O)([O-])OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(Cl)C=C3N[C@H](C4=CC=CC=C4F)C)=C3C=N2)O1.[NH4+].[NH4+]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    AB-680 ammonium Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    AB-680AB680AB 680CD73ecto-5′-nucleotidase, NT5Epotentreversible. selective. ecto-nucleotidaseecto-nucleotidasesCD39. anti-tumorInhibitorinhibitorinhibit

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