2. Immunology/Inflammation
  3. CD73
  4. AB-680

AB-680 

Cat. No.: HY-125286 Purity: 99.71% ee.: 99.96%
COA Handling Instructions

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity.

For research use only. We do not sell to patients.

AB-680 Chemical Structure

AB-680 Chemical Structure

CAS No. : 2105904-82-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 383 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 383 In-stock
Solid
5 mg USD 300 In-stock
10 mg USD 480 In-stock
25 mg USD 950 In-stock
50 mg USD 1450 In-stock
100 mg USD 2250 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 5 publication(s) in Google Scholar

Other Forms of AB-680:

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  • Biological Activity

  • Purity & Documentation

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Description

AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

IC50 & Target

Ki: 4.9 pM (hCD73)[1]
IC50: 43 pM (Soluble hCD73)[1]
In Vitro

AB-680 (AB680) inhibits soluble hCD73 with an IC50 of 0.043 nM, also inhibits hCD73 in CHO cells, suppresses CD73 in human, mouse CD8+ T Cells and hPBMC, with IC50s of 0.070, 0.008, 0.66 and 0.011 nM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

580.82

Appearance

Solid

Formula

C20H24ClFN4O9P2
CAS No.
SMILES

O=P(CP(O)(O)=O)(O)OC[[email protected]@H]1[[email protected]@H](O)[[email protected]@H](O)[[email protected]](N2C(N=C(Cl)C=C3N[[email protected]](C4=CC=CC=C4F)C)=C3C=N2)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (344.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7217 mL 8.6085 mL 17.2170 mL
5 mM 0.3443 mL 1.7217 mL 3.4434 mL
10 mM 0.1722 mL 0.8609 mL 1.7217 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (12.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 7.5 mg/mL (12.91 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (12.91 mM); Clear solution

  • 4.

    Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

    Solubility: ≥ 2.5 mg/mL (4.30 mM); Clear solution

  • 5.

    Add each solvent one by one:  5% DMSO    95% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.30 mM); Suspended solution; Need ultrasonic

  • 6.

    Add each solvent one by one:  1% DMSO    99% saline

    Solubility: ≥ 0.5 mg/mL (0.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.71% ee.: 99.96%

COA (251 KB) HNMR (224 KB) RP-HPLC (111 KB) NP-HPLC (140 KB) LCMS (118 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AB-6802105904-82-1AB680AB 680CD73ecto-5′-nucleotidase, NT5EInhibitorinhibitorinhibit

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