1. Apoptosis
  2. Bcl-2 Family
  3. CCT369260

CCT369260 

Cat. No.: HY-129188 Purity: 99.16%
Handling Instructions

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM.

For research use only. We do not sell to patients.

CCT369260 Chemical Structure

CCT369260 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 504 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3800 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM[1].

IC50 & Target

IC50: 520 nM (BCL6)[1].

In Vivo

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OCI-Ly1 DLBCL xenograft model (female SCID mice)[1].
Dosage: 15 mg/kg.
Administration: PO, single dose.
Result: Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
Animal Model: Female Balb/C mice[1].
Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration: IV and PO
Result: Demonstrated moderate clearance (CL 20 mL min−1 kg−1) with mean oral bioavailability of 54%.
Molecular Weight

508.99

Formula

C₂₄H₃₁ClF₂N₆O₂

SMILES

O=C1N(CCC(C)(O)C)C2=CC(NC3=NC(N4C[[email protected]@H](C)C(F)(F)[[email protected]@H](C)C4)=NC=C3Cl)=CC=C2N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (589.40 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9647 mL 9.8234 mL 19.6468 mL
5 mM 0.3929 mL 1.9647 mL 3.9294 mL
10 mM 0.1965 mL 0.9823 mL 1.9647 mL
*Please refer to the solubility information to select the appropriate solvent.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

CCT369260CCT 369260CCT-369260Bcl-2 FamilyInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CCT369260
Cat. No.:
HY-129188
Quantity:
MCE Japan Authorized Agent: