1. Apoptosis
  2. Bcl-2 Family
  3. CCT369260

CCT369260 

Cat. No.: HY-129188
Handling Instructions

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM.

For research use only. We do not sell to patients.

CCT369260 Chemical Structure

CCT369260 Chemical Structure

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Description

CCT369260 (compound 1) is an orally avtive B-cell lymphoma 6 (BCL6) inhibitor with anti-tumor activity. CCT369260 (compound 1) exhibits an IC50 of 520 nM[1].

IC50 & Target

IC50: 520 nM (BCL6)[1].

In Vivo

CCT369260 (compound 1, 15 mg/kg, po, single dose) significantly inhibits BCL6 in OCI-Ly1 DLBCL xenograft model[1].

Animal Model: OCI-Ly1 DLBCL xenograft model (female SCID mice)[1].
Dosage: 15 mg/kg.
Administration: PO, single dose.
Result: Decreased the levels of BCL6 in the tumor observed up to 10 h after administration.
Animal Model: Female Balb/C mice[1].
Dosage: 1 mg/kg iv and 5 mg/kg po (Pharmacokinetic Analysis).
Administration: IV and PO
Result: Demonstrated moderate clearance (CL 20 mL min−1 kg−1) with mean oral bioavailability of 54%.
Molecular Weight

508.99

Formula

C₂₄H₃₁ClF₂N₆O₂

SMILES

O=C1N(CCC(C)(O)C)C2=CC(NC3=NC(N4C[[email protected]@H](C)C(F)(F)[[email protected]@H](C)C4)=NC=C3Cl)=CC=C2N1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CCT369260CCT 369260CCT-369260Bcl-2 FamilyInhibitorinhibitorinhibit

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CCT369260
Cat. No.:
HY-129188
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