1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. Rosabulin

Rosabulin (Synonyms: STA 5312)

Cat. No.: HY-14934
Handling Instructions

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity.

For research use only. We do not sell to patients.

Rosabulin Chemical Structure

Rosabulin Chemical Structure

CAS No. : 501948-05-6

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Description

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity[1].

In Vitro

Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

400.45

Formula

C₂₂H₁₆N₄O₂S

CAS No.
SMILES

O=C(NC1=CC(C)=NS1)C(C2=C3C=CC=CN3C(CC4=CC=C(C#N)C=C4)=C2)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

RosabulinSTA 5312STA5312STA-5312Microtubule/Tubulinhematologicsolidtumorsanti-tumormicrotubuleassemblyInhibitorinhibitorinhibit

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Rosabulin
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HY-14934
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