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  4. (Rac)-Shikonin

(Rac)-Shikonin  (Synonyms: Shikalkin)

Cat. No.: HY-N6004 Purity: 98.95%
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(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer agent resistance by induction of a necroptotic death.

For research use only. We do not sell to patients.

(Rac)-Shikonin Chemical Structure

(Rac)-Shikonin Chemical Structure

CAS No. : 54952-43-1

Size Price Stock Quantity
5 mg USD 25 In-stock
10 mg USD 40 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

(Rac)-Shikonin (Shikonin) possesses anti-tumor activity. (Rac)-Shikonin (Shikonin) circumvents cancer agent resistance by induction of a necroptotic death[1][2].

In Vitro

Shikonin shows a similar potency toward drug-sensitive cancer cell lines (MCF-7 and HEK293) and their drug-resistant lines overexpressing P-glycoprotein, Bcl-2, or Bcl-xL, which account for most of the clinical cancer drug resistance[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

288.30

Formula

C16H16O5

CAS No.
Appearance

Solid

Color

Brown to reddish brown

SMILES

OC1=C2C(C(C=C(C(C/C=C(C)/C)O)C2=O)=O)=C(O)C=C1

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (433.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4686 mL 17.3430 mL 34.6861 mL
5 mM 0.6937 mL 3.4686 mL 6.9372 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4686 mL 17.3430 mL 34.6861 mL 86.7152 mL
5 mM 0.6937 mL 3.4686 mL 6.9372 mL 17.3430 mL
10 mM 0.3469 mL 1.7343 mL 3.4686 mL 8.6715 mL
15 mM 0.2312 mL 1.1562 mL 2.3124 mL 5.7810 mL
20 mM 0.1734 mL 0.8672 mL 1.7343 mL 4.3358 mL
25 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4686 mL
30 mM 0.1156 mL 0.5781 mL 1.1562 mL 2.8905 mL
40 mM 0.0867 mL 0.4336 mL 0.8672 mL 2.1679 mL
50 mM 0.0694 mL 0.3469 mL 0.6937 mL 1.7343 mL
60 mM 0.0578 mL 0.2891 mL 0.5781 mL 1.4453 mL
80 mM 0.0434 mL 0.2168 mL 0.4336 mL 1.0839 mL
100 mM 0.0347 mL 0.1734 mL 0.3469 mL 0.8672 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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(Rac)-Shikonin
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