1. Immunology/Inflammation
  2. CD73
  3. CD73-IN-14

D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CD73-IN-14 Chemical Structure

CD73-IN-14 Chemical Structure

CAS No. : 2407356-67-4

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Description

D73-IN-14 is a potent, selective and orally active CD73 inhibitor with an IC50 value of 0.17 nM. CD73-IN-14 increases the number of tumor-infiltrating CD8+ cells and shows anti-tumor activity[1]. CD73-IN-14 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

C50: 0.17 nM (CD73)[1]

In Vivo

CD73-IN-14 (10, 25, 50 mg/kg; p.o.; twice-a-day for 20 days) shows anti-tumor activity in mouse[1].br/> Pharmacokinetic Parameters of CD73-IN-14 in rats[1].

PO Dose (mg/kg) AUC0-24 h (ng*hr/mL) Cmax(nM) Tmax(hr)
50 580 74 0.8
200 6094 1800 0.8
500 18500 11000 0.3
rats, 50, 200, 500 mg/kg p.o.[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (EG7 model)[1]
Dosage: 10, 25, 50 mg/kg
Administration: P.o.; twice a day for 20 days
Result: Increased tumor-infiltrating CD8+ cells and decreased the tumor volume in a dose dependet manner.
Molecular Weight

615.98

Formula

C26H26ClN7O9

CAS No.
SMILES

ClC1=NC2=C(N=CN2[C@H]3[C@@H]([C@@](C#C)([C@H](O3)COC(CC4=CC=C(C=C4)N5C(NCCC5)=O)(C(O)=O)C(O)=O)O)O)C(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CD73-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
CD73-IN-14
Cat. No.:
HY-152074
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