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Prexasertib lactate

(Synonyms: LY2606368 lactate)
37 Cited Publications
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Based on 37 publication(s) in Google Scholar

Prexasertib lactate (LY2606368 lactate) is the lactate form of Prexasertib (HY-18174). Prexasertib lactate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib lactate inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib lactate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib lactate shows potent anti-tumor activity.

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  • CAS No.: 2781996-46-9
  • Formule: C21H25N7O5
  • Masse moléculaire:455.47
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Prexasertib lactate Chemical Structure
    Prexasertib lactate Chemical Structure
  • Experimental Validation Results for Prexasertib lactate
  • Experimental Validation Results for Prexasertib lactate
  • Experimental Validation Results for Prexasertib lactate
  • Experimental Validation Results for Prexasertib lactate
  • Experimental Validation Results for Prexasertib lactate
  • Experimental Validation Results for Prexasertib lactate
CAS No.: 2781996-46-9
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Cell Proliferation/Viability AssayWBFlow CytometryIn Vivo Efficacy StudyApoptosis AnalysisRT-PCR
  • WB
  • Flow Cytometry
  • In Vivo Efficacy Study
  • Apoptosis Analysis
  • RT-PCR
  • Cell Proliferation/Viability Assay

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  • Prexasertib lactate Chemical Structure
    Prexasertib lactate Chemical Structure
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    Prexasertib lactate purchased from MedChemExpress. Usage Cited in: Br J Cancer. 2021 Jul;125(1):101-111. [Abstract]

    Customer Validation
     Full length and cleaved PARP protein expressions are determined by western blot in Hepa1-6 cells and Huh-7 cells induced by prexasertib with dose of 1 µM and 5 nM for 24 h, respectively.

  • 1/16

    Prexasertib lactate purchased from MedChemExpress. Usage Cited in: Br J Cancer. 2021 Jul;125(1):101-111. [Abstract]

    Customer Validation
     Representative image of FACS analysis of late apoptotic Hepa1-6 cell rate treated by DMSO or prexasertib with dose of 1 µM for 24 h are shown.

  • 1/16

    Prexasertib lactate purchased from MedChemExpress. Usage Cited in: Br J Cancer. 2021 Jul;125(1):101-111. [Abstract]

    Customer Validation
     Tumour growth curves (Mean ± SEM) of murine HCC model treated by vehicle (n = 8) or prexasertib (10mg/kg, subcutaneous injection, 2 of 7 days, n = 8) are shown.

  • 1/16

    Prexasertib lactate purchased from MedChemExpress. Usage Cited in: Br J Cancer. 2021 Jul;125(1):101-111. [Abstract]

    Customer Validation
     Prexasertib (10mg/kg, subcutaneous injection, 2 of 7 days). Representative images of TUNEL assay for cellular apoptosis (green staining) in tumours are shown.

  • 1/16

    Prexasertib lactate purchased from MedChemExpress. Usage Cited in: Br J Cancer. 2021 Jul;125(1):101-111. [Abstract]

    Customer Validation
     Prexasertib (10mg/kg, subcutaneous injection, 2 of 7 days, n = 8). PD-L1 mRNA expression is determined by qPCR in tumours treated by prexasertib or vehicle.

  • 1/16

    Prexasertib lactate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Aug 2;10(1):3485. [Abstract]

    Customer Validation
     Viability of mock control and Myc-activated CRISPRa cells upon treatment with 40 nM prexasertib for 96 h (n = 3).

  • Prexasertib lactate