2. Antibody-drug Conjugate/ADC Related Protein Tyrosine Kinase/RTK
  3. ADC Antibody c-Met/HGFR
  4. Zevontabart

Zevontabart  (Synonyms: MYTX-011 Antibody; Q-397)

Cat. No.: HY-P992146
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Zevontabart (MYTX-011 Antibody; Q-397) is a pH-dependent anti-c-MET antibody. Zevontabart regulates the trafficking process of c-MET to reduce receptor recycling, and enhances its own endocytosis and accumulation in c-MET-expressing cells. Zevontabart induces cytotoxicity in solid tumor cells and exerts anti-tumor activity in a non-small cell lung cancer xenograft mouse model. Zevontabart can be used to synthesize ADC, such as: MYTX-011. Zevontabart can be used in studies related to non-small cell lung cancer, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001).

For research use only. We do not sell to patients.

Zevontabart

Zevontabart Chemical Structure

CAS No. : 3060218-90-5

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Zevontabart Related Antibodies

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Description

Zevontabart (MYTX-011 Antibody; Q-397) is a pH-dependent anti-c-MET antibody. Zevontabart regulates the trafficking process of c-MET to reduce receptor recycling, and enhances its own endocytosis and accumulation in c-MET-expressing cells. Zevontabart induces cytotoxicity in solid tumor cells and exerts anti-tumor activity in a non-small cell lung cancer xenograft mouse model. Zevontabart can be used to synthesize ADC, such as: MYTX-011. Zevontabart can be used in studies related to non-small cell lung cancer, with its corresponding isotype control being Human IgG1 kappa, Isotype Control (HY-P99001)[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

Zevontabart (50 nM; 120 s association, 300 s dissociation) binds to recombinant human c-MET in a pH-dependent manner, with a faster dissociation rate at the endolysosomal pH of 5.4 compared to the neutral pH of 7.4[1].
Zevontabart (10 nM; 0.5-3 h) accumulates highly in lysosomes of NCI-H1975 c-MET+ non-small cell lung cancer (NSCLC) cells[1].
Zevontabart (25 nM; 30 min) shows low colocalization with Rab4+ rapidly recycling endosomes in EBC-1 c-MET+ cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zevontabart Related Antibodies

Immunofluorescence[1]

Cell Line: NCI-H1975 (c-MET+ NSCLC) cells transfected with LAMP1-RFP (lysosomal marker)
Concentration: 10 nmol/L
Incubation Time: 30 min, 1 h, 3 h
Result: Showed equivalent colocalization with LAMP1-RFP+ lysosomes to the parent mAb at all time points, but exhibited significantly higher fluorescence intensity within lysosomes relative to the parent mAb.

Immunofluorescence[1]

Cell Line: EBC-1 (c-MET+ cancer) cells transfected with Rab4-mRuby (fast-recycling endosome marker)
Concentration: 25 nmol/L
Incubation Time: 30 min
Result: Showed significantly lower colocalization with Rab4-mRuby+ fast-recycling endosomes relative to the parent mAb.
Parmacokinetics
Species Dose Route T1/2
Cynomolgus Monkey[1] 2.7 mg/kg i.v. 158
In Vivo

Zevontabart (0-6 mg/kg; i.v.; single administration) exhibits antitumor efficacy in NCI-H1975 NSCLC, NCI-H1373 NSCLC (with moderate c-MET expression), EBC-1 (with high c-MET expression), and NCI-H2122 NSCLC (with low c-MET expression) xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (6-8-week-old female; non-small cell lung cancer xenograft model)[1]
Dosage: 0.5 mg/kg; 1 mg/kg; 2 mg/kg; 4 mg/kg; 6 mg/kg
Administration: i.v.; single dose
Result: Significantly reduced tumor size and more effectively slowed tumor growth.
Gene ID

4233  [NCBI]

Accession
Target

HGFR/c-Met
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS No.
SMILES

[Zevontabart]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zevontabart Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zevontabart3060218-90-5MYTX-011 Antibody Q-397Q397Q 397Q-397ADC Antibodyc-Met/HGFRc-METnon-small cell lung cancerNCI-H1975 cellsEBC-1 cellsSCID miceInhibitorinhibitorinhibit

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