2. Apoptosis
  3. Apoptosis
  4. IMB5046

IMB5046 is a microtubule inhibitor that induces apoptosis by blocking the G2/M phase of the cell cycle. IMB5046 has anti-tumor activity.

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IMB5046

IMB5046 Chemical Structure

CAS No. : 1001571-08-9

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Based on 1 publication(s) in Google Scholar

IMB5046 Related Antibodies

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Description

IMB5046 is a microtubule inhibitor that induces apoptosis by blocking the G2/M phase of the cell cycle. IMB5046 has anti-tumor activity[1].

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
0.01 μM
Compound: IMB5046
Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
Bel-7402 IC50
0.056 μM
Compound: IMB5046
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
Bel-7402 IC50
0.268 μM
Compound: IMB5046
Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against ADR-resistant human Bel-7402 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
H22 IC50
0.025 μM
Compound: IMB5046
Antiproliferative activity against mouse H22 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse H22 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
HCT-8 IC50
0.027 μM
Compound: IMB5046
Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
HCT-8 IC50
0.221 μM
Compound: IMB5046
Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against taxol-resistant human HCT-8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
HepG2 IC50
0.033 μM
Compound: IMB5046
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
K562 IC50
0.01 μM
Compound: IMB5046
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
K562/VCR IC50
0.297 μM
Compound: IMB5046
Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against VCR resistant human K562/VCR cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
L02 IC50
0.044 μM
Compound: IMB5046
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
MDA-MB-231 IC50
0.031 μM
Compound: IMB5046
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 33676300]
Molecular Weight

388.44

Formula

C19H20N2O5S
CAS No.
SMILES

O=C(OCC1=CC=C(SC)C=C1)C2=CC([N+]([O-])=O)=CC=C2N3CCOCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IMB5046 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IMB50461001571-08-9IMB 5046IMB-5046ApoptosisMicrotubuleinhibitoranti-tumorInhibitorinhibit

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