1. Cell Cycle/DNA Damage
    Apoptosis
  2. DNA Alkylator/Crosslinker
    Apoptosis
  3. Illudin M

Illudin M 

Cat. No.: HY-122493
Handling Instructions

Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus olearius mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities.

For research use only. We do not sell to patients.

Illudin M Chemical Structure

Illudin M Chemical Structure

CAS No. : 1146-04-9

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Description

Illudin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus olearius mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities[1][2].

In Vitro

Illudin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro[1].

Apoptosis Analysis[1]

Cell Line: Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs)
Concentration: 0.01 μM, 1 μM, 10 μM
Incubation Time: 24 hours, 48 hours,72 hours, 96 hours, 120 hours
Result: Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
Molecular Weight

248.32

Formula

C₁₅H₂₀O₃

CAS No.

1146-04-9

SMILES

O=C1C2=CC(C)([[email protected]@H](C2=C(C3([[email protected]@]1(C)O)CC3)C)O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Illudin MDNA Alkylator/CrosslinkerApoptosisalkylateDNA alkylationcytotoxicityInhibitorinhibitorinhibit

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