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Cat. No.: HY-133760

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MI-888

MI-888 is an orally active MDM2 inhibitor with a K_i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 1303607-59-1
Formula: C₂₈H₃₂Cl₂FN₃O₃
Molecular Weight:548.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

MI-888 Chemical Structure

CAS No.: 1303607-59-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MI-888 is an orally active MDM2 inhibitor with a K_i of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	>10 μM Compound: 9, MI-888	Cytotoxicity against p53-deficient human HCT116 cells assessed as growth inhibition by WST-8 assay Cytotoxicity against p53-deficient human HCT116 cells assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
HCT-116	IC₅₀	92 nM Compound: 9, MI-888	Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human HCT116 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
RS4-11	IC₅₀	0.06 μM Compound: 9, MI-888	Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human RS4:11 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]
SJSA-1	IC₅₀	0.08 μM Compound: 9, MI-888	Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay Cytotoxicity against human SJSA1 cells expressing wild type p53 assessed as growth inhibition by WST-8 assay	[PMID: 23786219]

Chemical Information

CAS No. 1303607-59-1
Molecular Weight 548.48
Formula C₂₈H₃₂Cl₂FN₃O₃
SMILES

CC(C)(C)C[C@H]1[C@]2(C3=CC=C(Cl)C=C3NC2=O)[C@@H](C4=C(C(Cl)=CC=C4)F)[C@@H](N1)C(N[C@H]5C[C@@](O)(C5)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao Y, et al. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem. 2013 Jul 11;56(13):5553-61. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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