1303607-59-1
Chemical Structure
MI-888
- CAS No.: 1303607-59-1
- Formula:C28H32Cl2FN3O3
- Molecular Weight:548.48
IUPAC Name: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-N-((1s,3S)-3-hydroxy-3-methylcyclobutyl)-2'-neopentyl-2-oxospiro[indoline-3,3'-pyrrolidine]-5'-carboxamide
InChIKey: MZBOZBMARIQZGX-GRRGFIRHSA-N
SMILES: CC(C)(C)C[C@H]1[C@]2(C3=CC=C(Cl)C=C3NC2=O)[C@@H](C4=C(C(Cl)=CC=C4)F)[C@@H](N1)C(N[C@H]5C[C@@](O)(C5)C)=O
Biological Activity: MI-888 is an orally active MDM2 inhibitor with a Ki of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity[1].
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MI-888 | MI-888 is an orally active MDM2 inhibitor with a Ki of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity. | |||||||||||||||||||||
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Keywords
