2. Others Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Reference Standards PARP Apoptosis
  4. Niraparib tosylate hydrate (Standard)

Niraparib tosylate hydrate (Standard)  (Synonyms: MK-4827 tosylate hydrate (Standard))

Cat. No.: HY-10619ER
Handling Instructions Technical Support

Niraparib tosylate hydrate (Standard) is the analytical standard of Niraparib tosylate hydrate (HY-10619E). This product is intended for research and analytical applications. Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.

For research use only. We do not sell to patients.

Niraparib tosylate hydrate (Standard)

Niraparib tosylate hydrate (Standard) Chemical Structure

CAS No. : 1613220-15-7

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Information

Niraparib tosylate hydrate (Standard) is the analytical standard of Niraparib tosylate hydrate (HY-10619E). This product is intended for research and analytical applications. Niraparib (MK-4827) tosylate hydrate is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib tosylate hydrate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

510.61

Formula

C26H30N4O5S
CAS No.
SMILES

NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.O=S(C5=CC=C(C)C=C5)(O)=O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Niraparib tosylate hydrate (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Niraparib tosylate hydrate (Standard)1613220-15-7MK-4827 tosylate hydrate (Standard)Reference StandardsPARPApoptosispoly ADP ribose polymerase ovariancancerlungbreastDNAdamageanti-tumororallybioavailableInhibitorinhibitorinhibit

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