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Cat. No.: HY-143250

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Tubulin inhibitor 12

Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC₅₀=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity.

For research use only. We do not sell to patients.

CAS No.: 92575-00-3
Formula: C₂₄H₂₀N₂O
Molecular Weight:352.43

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Tubulin inhibitor 12 Chemical Structure

CAS No.: 92575-00-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC₅₀=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity^[1].

In Vitro

Tubulin inhibitor 12 (0-100 μM; 72 h) shows moderate and broad-spectrum anti-proliferative activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HepG2, A549, and HCT116 cells
Concentration:

0-100 μM
Incubation Time:

72 hours
Result:

Showed IC₅₀ values of 49.13, 52.84, and 70.10 μM for HepG2, A549, and HCT116 cells, respectively.

Chemical Information

CAS No. 92575-00-3
Molecular Weight 352.43
Formula C₂₄H₂₀N₂O
SMILES

CN(C(C1=CC(C2=CC=CC=C2)=NC3=CC=CC=C31)=O)CC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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