BIW-8962
BIW-8962 is a humanized anti-ganglioside GM2 antibody. BIW-8962 exhibits ADCC/CDC activity against multiple myeloma cells. BIW-8962 demonstrates potent anti-tumor activity in mouse xenograft models. BIW-8962 is indicated for research in myeloma and other cancers.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
Ganglioside GM2
BIW-8962 (0.01-1 μg/mL) has ADCC activity in GM2-expressing SBC-3 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SBC-3 cells
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Concentration:0, 0.1, 1, 10 ug/mL
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Incubation Time:72 h at 37 ℃
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Result:Inhibited cell viability
BIW-8962 (0.1-10 μg/100μL, i.v., once a day, on days 7, 14, 21, 28, and 35 after injection of SBC-3 cells) inhibits tumor multiple organ metastases, increases the number apoptotic cells, prolongs survival in SBC-3 SCID mice depleted of natural killer cells model[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KMS-11 SCID mice model[1]
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Dosage:0.1 mg/kg
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Administration:i.v., biweekly for 3 weeks
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Result:Exhibited a potent anti-tumor activity.
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Animal Model:OPM-2/GFP SCID mice model[1]
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Dosage:10 mg/kg
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Administration:i.v., biweekly for 4 weeks
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Result:Suppressed OPM-2/GFP cell growth and serum M protein elevation.
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Animal Model:SBC-3 (106) SCID mice (5-6 weeks) depleted of natural killer cells model[2]
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Dosage:0.1,1,10 μg/100μL
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Administration:i.v., once a day, on days 7, 14, 21, 28, and 35 after injection of SBC-3 cells
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Result:Inhibited multiple organ metastases of SBC-3 cells, increased the number of TUNEL-positive apoptotic cells, prolonged survival of the mice compared with control.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay
Chemical Information
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SMILES
N/A
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BIW-8962 Related Classifications
HY-P991639 Related Classifications
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