2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Apoptosis
  3. PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis
  4. 4,4′-Secalonic acid D

4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity.

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4,4′-Secalonic acid D

4,4′-Secalonic acid D Chemical Structure

CAS No. : 2265910-52-7

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4,4′-Secalonic acid D Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Description

4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
11.7 μM
Compound: 7
Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
HCT-116 IC50
0.5 μM
Compound: 7
Cytotoxicity against human HCT116 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
HL-60 IC50
0.9 μM
Compound: 7
Cytotoxicity against human HL60 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
K562 IC50
0.4 μM
Compound: 7
Cytotoxicity against human K562 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
MGC-803 IC50
0.9 μM
Compound: 7
Cytotoxicity against human MGC803 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human MGC803 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
NCI-H1975 IC50
3.5 μM
Compound: 7
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay
[PMID: 29466776]
Molecular Weight

638.57

Formula

C32H30O14
CAS No.
SMILES

O[C@H]1[C@](C2=C(O)C[C@@H]1C)(C(OC)=O)OC3=C(C4=C(O[C@]5(C(OC)=O)C(C6=O)=C(O)C[C@H](C)[C@H]5O)C6=C(O)C=C4)C=CC(O)=C3C2=O
Structure Classification
Initial Source

Paraconiothyrium sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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4,4′-Secalonic acid D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4,4′-Secalonic acid D2265910-52-7PARPReactive Oxygen Species (ROS)CaspaseApoptosisPyroptosispoly ADP ribose polymerase HepG2WRL68Inhibitorinhibitorinhibit

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