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Cat. No.: HY-N15380

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4,4′-Secalonic acid D

4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity.

For research use only. We do not sell to patients.

CAS No.: 2265910-52-7
Formula: C₃₂H₃₀O₁₄
Molecular Weight:638.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

4,4′-Secalonic acid D Chemical Structure

CAS No.: 2265910-52-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Classifications
Bioz

Biological Activity

Description

All PARP Isoforms :

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	11.7 μM Compound: 7	Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay	[PMID: 29466776]
HCT-116	IC₅₀	0.5 μM Compound: 7	Cytotoxicity against human HCT116 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay	[PMID: 29466776]
HL-60	IC₅₀	0.9 μM Compound: 7	Cytotoxicity against human HL60 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay	[PMID: 29466776]
K562	IC₅₀	0.4 μM Compound: 7	Cytotoxicity against human K562 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human K562 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay	[PMID: 29466776]
MGC-803	IC₅₀	0.9 μM Compound: 7	Cytotoxicity against human MGC803 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human MGC803 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay	[PMID: 29466776]
NCI-H1975	IC₅₀	3.5 μM Compound: 7	Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as reduction in cell proliferation after 48 hrs by MTT assay	[PMID: 29466776]

Chemical Information

CAS No. 2265910-52-7
Molecular Weight 638.57
Formula C₃₂H₃₀O₁₄
SMILES

O[C@H]1[C@](C2=C(O)C[C@@H]1C)(C(OC)=O)OC3=C(C4=C(O[C@]5(C(OC)=O)C(C6=O)=C(O)C[C@H](C)[C@H]5O)C6=C(O)C=C4)C=CC(O)=C3C2=O
Structure Classification
- Phenols
- Xanthones
Initial Source
- Animals
Paraconiothyrium sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang MK, et al. Structurally diverse tetrahydroxanthone analogues from Paraconiothyrium sp. AC31 with pyroptosis induction through targeted inhibition of PARP1 in hepatocellular carcinoma cells. Bioorg Chem. 2025 Feb 26;157:108310. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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4,4′-Secalonic acid D

All PARP Isoforms

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

4,4′-Secalonic acid D Related Classifications

HY-N15380 Related Classifications