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Results for "

inhibitory+activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	11β-HSD (2) 5 alpha Reductase (1) 5-HT Receptor (5) AAK1 (2) Acetolactate Synthase (ALS) (2) Acetyl-CoA Carboxylase (1) Acetyl-CoA synthetase (1) Ack1 (1) Acyltransferase (5) ADC Payload (4) Adenosine Kinase (1) Adenosine Receptor (3) Adenylate Cyclase (1) Adrenergic Receptor (2) Akt (34) Aldehyde Dehydrogenase (ALDH) (2) Aldose Reductase (7) Amino Acid Derivatives (4) Aminoacyl-tRNA Synthetase (1) Aminopeptidase (3) AMPK (5) Amylases (8) Amyloid-β (15) Anaplastic lymphoma kinase (ALK) (13) Androgen Receptor (2) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (13) Antibiotic (71) Antifolate (4) Apoptosis (115) Arginase (15) Aryl Hydrocarbon Receptor (3) ASK1 (2) Atg7 (2) Atg8/LC3 (2) ATP Citrate Lyase (1) ATP Synthase (1) Aurora Kinase (3) AUTACs (1) Autophagy (23) Bacterial (214) Bcl-2 Family (13) Bcr-Abl (7) BCRP (2) Beta-lactamase (6) Beta-secretase (9) Biochemical Assay Reagents (14) Bradykinin Receptor (2) Btk (5) c-Kit (4) c-Met/HGFR (8) c-Myc (2) 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(2) IDE (1) IFNAR (2) IGF-1R (1) iGluR (5) IKK (5) IMPDH (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (28) Insecticide (11) Insulin Receptor (1) Integrin (2) Interleukin Related (31) IRE1 (1) Isocitrate Dehydrogenase (IDH) (3) Isotope-Labeled Compounds (30) JAK (11) JNK (15) Kallikrein (1) Keap1-Nrf2 (7) Kinesin (2) Lactate Dehydrogenase (3) LAG-3 (1) Large Tumor Suppressor (LATS) (2) Leukotriene Receptor (1) Ligands for E3 Ligase (1) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) Lipase (3) Lipoxygenase (13) LPL Receptor (2) LRRK2 (1) mAChR (4) MAGL (3) MAP3K (2) MAP4K (2) MAPKAPK2 (MK2) (1) MARCKS (1) MARK (1) MDM-2/p53 (6) MEK (4) Melanocortin Receptor (1) MetAP (1) Methionine Adenosyltransferase (MAT) (2) METTL3 (1) mGluR (2) MicroRNA (1) Microtubule/Tubulin (12) Mineralocorticoid Receptor (1) Mitochondrial Metabolism (7) MMP (21) MNK (3) MOFs (2) Molecular Glues (2) Monoamine Oxidase (23) Mps1 (2) mTOR (9) Myosin (5) Na+/H+ Exchanger (NHE) (3) Na+/K+ ATPase (3) nAChR (2) NADPH Oxidase (1) NAMPT (2) Necroptosis (4) Neprilysin (1) Neurokinin Receptor (1) NF-κB (33) NKCC (1) NO Synthase (30) NOD-like Receptor (NLR) (9) Notch (1) NTPDase (1) Nuclear Factor of activated T Cells (NFAT) (2) Nucleoside Antimetabolite/Analog (1) Nucleoside Transporters (2) OAT (1) Opioid Receptor (4) Orexin Receptor (OX Receptor) (1) Organoid (2) Orthopoxvirus (4) Oxidative Phosphorylation (1) P-glycoprotein (5) P2Y Receptor (1) p38 MAPK (27) p62 (1) p97 (1) PAI-1 (3) Parasite (39) PARP (9) PCSK9 (1) PD-1/PD-L1 (5) PDGFR (7) PDI (4) Penicillin-binding protein (PBP) (1) PERK (3) PGE synthase (2) Phosphatase (16) Phosphodiesterase (PDE) (27) Phospholipase (4) Phosphorylase (2) Phytohormone (1) PI3K (13) PI4K (2) Pim (4) PKA (3) PKC (9) PKD (3) PKG (1) Plasminogen/Plasmin (1) Platelet-activating Factor Receptor (PAFR) (5) Polo-like Kinase (PLK) (5) Potassium Channel (8) PPAR (7) Progesterone Receptor (1) Prolyl Endopeptidase (PREP) (4) Prostaglandin Receptor (11) PROTACs (18) Protease Activated Receptor (PAR) (1) Proteasome (8) Proteolytic Enzyme (1) Proton Pump (3) Protoporphyrinogen IX oxidase (1) PSMA (1) Pyroptosis (4) Quinone Reductase (1) RAD51 (1) Raf (6) RANKL/RANK (3) Ras (12) Reactive Oxygen Species (ROS) (43) Reference Standards (77) Renin (4) RET (3) REV-ERB (1) Reverse Transcriptase (13) Ribosomal S6 Kinase (RSK) (2) RIG-I-like receptor (RLR) (1) RIP kinase (4) RNA MTase (1) ROCK (7) ROR (1) ROS Kinase (2) RSV (3) Salt-inducible Kinase (SIK) (2) SARS-CoV (21) Ser/Thr Kinase (5) Ser/Thr Protease (7) Serotonin Transporter (4) SF3B1 (1) SGK (1) SGLT (1) SHP1 (2) SHP2 (4) Sigma Receptor (5) Sirtuin (3) Small Interfering RNA (siRNA) (2) SOD (3) Sodium Channel (6) SOS1 (2) Src (5) STAT (16) Stearoyl-CoA Desaturase (SCD) (1) Steroid Sulfatase (1) STING (4) Succinate Dehydrogenase (3) SULT (1) Survivin (2) TAM Receptor (2) Tau Protein (5) Telomerase (3) TGF-beta/Smad (4) TGF-β Receptor (5) Thrombin (3) Thymidylate Synthase (4) TMV (4) TNF Receptor (32) Toll-like Receptor (TLR) (9) TOPK (2) Topoisomerase (20) Transketolase (1) Trk Receptor (2) TRP Channel (7) TrxR (2) Tyrosinase (23) Urease (1) VEGFR (11) Virus Protease (6) Wee1 (2) Wnt (6) Xanthine Oxidase (17) YAP (8) α-synuclein (2) β-catenin (6) β-glucuronidase (2)
By Research Areas:	Cancer (561) Cardiovascular Disease (87) Endocrinology (12) Infection (440) Inflammation/Immunology (286) Metabolic Disease (138) Neurological Disease (185)
Click Chemistry:	Azide (3) Tetrazine (1) Alkynes (7)
Oligonucleotides:	Solvents (1) Fillers (1) Nucleotide Analogs (1) Solubilizing Agents (1) siRNA drugs (2) Freeze-drying Protective Agents (1) Uracil Nucleotide (1) Uracil (1) Phosphoramidites (1) Cholesterol (1) siRNAs (2)

1544

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

405

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

GMP Molecules

S-(+)-Marmesin (+)-Marmesin; (S)-Marmesin	COX Lipoxygenase	Others
S-(+)-Marmesin is a natural coumarin, exhibiting COX-2/5-LOX dual inhibitory activity.

DJ001	Phosphatase Apoptosis	Inflammation/Immunology
DJ001 is a highly specific, selective and non-competitive protein tyrosine phosphatase-σ (PTPσ) inhibitor with an IC₅₀ of 1.43 μM. DJ001 displays no inhibitory activity against other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5. DJ001 promotes promote hematopoietic stem cell regeneration .

Diclofenac acyl glucuronide D-1-O-G	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT	Inflammation/Immunology
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of OATP2B1. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

ARM1 1 Publications Verification 4BSA	Aminopeptidase Epoxide Hydrolase	Cancer
ARM1 (4BSA) is a potent aminopeptidase and epoxide hydrolase inhibitor. ARM1 shows aminopeptidase inhibitory activity with an IC₅₀ 7.61 µM and epoxide hydrolase inhibitory activity with an IC₅₀ 12.4 µM .

DL-Homocysteine thiolactone hydrochloride	Endogenous Metabolite	Others
DL-Homocysteine thiolactone hydrochloride is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

Z-Gly-Pro-pNA	Prolyl Endopeptidase (PREP)	Others
Z-Gly-Pro-pNA is a substrate for measuring prolyl endopeptidase (PEP) inhibitory activity .

Panasenoside	Glycosidase	Metabolic Disease
Panasenoside is a flavonoid isolated from Lilium pumilum DC. Panasenoside exhibits α-glucosidase inhibitory activity .

Manghaslin	Cholinesterase (ChE)	Inflammation/Immunology
Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC₅₀ of 94.92 μM .

Ganoderic acid C6	Aldose Reductase	Metabolic Disease
Ganoderic acid C6 has aldose reductase inhibitory activity .

Methylsticin	Others	Inflammation/Immunology
Methylsticin is a kavalactone isolated from the Piper methysticum . Methylsticin exhibit osteoclast formation inhibitory activity .

Somatostatin-25	GHSR	Neurological Disease
Somatostatin-25 is a endogenous neuropeptide hormone that shows inhibitory activity against secretion of growth hormone.

9-Deazaguanine 1 Publications Verification	DNA/RNA Synthesis	Others
9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP) .

Nuezhenidic acid	Influenza Virus	Infection
Nuezhenidic acid can be isolated from the fruits of Ligustrum lucidum, posseses inhibitory activities against influenza A virus .

Apixaban ethyl ester	Factor Xa	Cardiovascular Disease
Apixaban ethyl ester is a key intermediate in the synthesis of FXa inhibitors, which is used to study the inhibitory activity against venous thrombosis .

Lyciumin A	Angiotensin-converting Enzyme (ACE) Renin	Cardiovascular Disease
Lyciumin A, a cyclic octapeptide, exhibits inhibitory activity on proteases, renin and angiotensin-converting enzyme. Lyciumin A can be used for the research of hypertension .

Histargin	Carboxypeptidase	Metabolic Disease
Histargin is a selective carboxypeptidase B inhibitor with an IC₅₀ of 17 μg/mL and a K_i of 30 μM. Histargin exerts competitive inhibition with substrate, with inhibitory activity abolished by metal cations. Histargin shows no significant inhibitory activity against carboxypeptidase A, aminopeptidase A, or aminopeptidase B .

Tenaxin I	Others	Others
Tenaxin I is a component extracted from Radix Scutellariae with neuraminidase inhibitory activity .

(S)-KT109	Endogenous Metabolite	Others
(S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM) .

Aureusidin	Lipoxygenase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Aureusidin is an aurone with high antioxidant and lipoxygenase inhibitory activity. Aureusidin also shows anti-inflammatory effects .

CDK9-IN-12	CDK	Cancer
CDK9-IN-12 displays the optimal CDK9 inhibitory activity with an IC₅₀ value of 5.41 nM.

Ethacizine-d5	Isotope-Labeled Compounds Sodium Channel	Cardiovascular Disease
Ethacizine-d₅ is the deuterium labeled Ethacizine (HY-131987). Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels.

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

Quercetin 3-O-glucoside-7-O-rhamnoside	Others	Neurological Disease
Quercetin 3-O-glucoside-7-O-rhamnoside is a member of flavonoid glycosides group with an inhibitory activity on the CNS .

Camellianin B	Angiotensin-converting Enzyme (ACE)	Metabolic Disease
Camellianin B, a flavonoid compound, is a Camellianin A metabolite. Camellianin B has antioxidant and angiotensin converting enzyme (ACE) inhibitory activities .

kb-NB77-78	PKD	Cancer
kb-NB77-78 is an analogue of CID797718, but shows no PKD inhibitory activity .

3-Epidehydrotumulosic acid	Others	Cardiovascular Disease
3-Epidehydrotumulosic acid has inhibitory activity against AAPH-induced lysis of red blood cells .

Matairesinoside 1 Publications Verification	Bacterial Fungal	Infection
Matairesinoside is a lignan with antibacterial and antioxidant activities. Matairesinoside also shows virus-cell fusion inhibitory activity .

Epinodosinol	Others	Cancer
Epinodosinol is a diterpenoid derived from plant Rabdosia angustifolia. Epinodosinol has inhibitory activity against certain cancer cells .

Ethacizine	Sodium Channel	Cardiovascular Disease
Ethacizine is an antiarrhythmic agent with inhibitory activity on sodium channels .

Pyrazine-2-carbothioamide	Bacterial	Infection
Pyrazine-2-carbothioamide is an effective antituberculosis agent with inhibitory activity against mycobacterium in vitro .

Nannochelin B	Bacterial Fungal	Infection
Nannochelin B is a novel citrate-hydroxamate siderophore with a growth-inhibitory activity against some bacteria and fungi .

Bisacurone	NO Synthase	Inflammation/Immunology
Bisacurone is a natural terpenoid, exhibits inhibitory activities on LPS-induced NO production with an IC₅₀ of 29.8 μM .

Poloxime	Polo-like Kinase (PLK)	Cancer
Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

LF 1695	Interleukin Related	Others
LF 1695 is an immunomodulator. LF 1695 enhances the proliferative response of T cells by increasing the production of IL2 (interleukin-2) or the expression of the IL2 receptor. LF 1695 also increases CONA-induced inhibitory activity in human lymphocytes. LF 1695 can be used to study the proliferative and inhibitory activity of T cell subpopulations, as well as their role in immune regulation .

Rubinaphthin A	TMV	Infection
Rubinaphthin A is a naphthohydroquinone that can be found in the roots of Rubia yunnanensis. Rubinaphthin A exhibits inhibitory activity against tobacco mosaic virus (TMV) .

AChE-IN-3	Cholinesterase (ChE)	Neurological Disease
AChE-IN-3 shows moderate inhibitory activity against AChE and strong NO inhibitory activity with an EC₅₀ of 0.57 μM.

Norharmine	Monoamine Oxidase DYRK	Others
Norharmine is a Harmine analogue and an alkaloid. Norharmine is the inhibitors of MAO-A and DYRK1A. Norharmine has weak inhibitory activity against MAO-A and certain inhibitory activity against DYRK1A .

Licoagrochalcone C	NF-κB	Inflammation/Immunology
Licoagrochalcone C, a flavonoid, reveals efficacious inhibitory activity on NF-κB transcription. Licoagrochalcone C shows significant inhibitory activity on LPS (HY-D1056)-induced NO production .

(+)-Cinchonaminone	Monoamine Oxidase	Others
(+)-Cinchonaminone shows monoamine oxidase (MAO) inhibitory activity.

Necroptosis-IN-4	Necroptosis RIP kinase	Inflammation/Immunology
Necroptosis-IN-4, a potent necroptosis inhibitor, is a RIP kinase 1 (RIPK1) inhibitor. Necroptosis-IN-4 has no inhibitory activity against RIPK3 and weak inhibitory activity against VEGFR1/2 and PDGFR-α .

Fluoropolyoxin L	Bacterial	Infection
Fluoropolyoxin L has the inhibitory activity of Escherichia coli and Streptococcus faecalis .

Dabequin phosphate	Parasite	Infection
Dabequin phosphate is an antimalarial agent, that exhibits inhibitory activity against Plasmodium falciparum .

Hydrocarbon chain derivative 1 6,6'-Oxybis[2,2-dimethyl-1-hexanol]	Drug Derivative	Metabolic Disease
Hydrocarbon chain derivative 1 is an active compound, with inhibitory activities against lipid synthesis.

Eupatoriochromene	Xanthine Oxidase	Others
Eupatoriochromene is a chromene and has inhibitory activity against xanthine oxidase (XO) .

PRMT5-IN-12	Histone Methyltransferase	Cancer
PRMT5-IN-12 shows remarkable inhibitory activity on PRMT5.

Adeninobananin	DNA/RNA Synthesis	Infection
Adeninobananin, a negative control tool, does not show any inhibitory activity of the SARS Coronavirus helicase.

Cat. No.	Product Name

HY-L051

Ferroptosis Compound Library

1,177 compounds

Ferroptosis is a novel type of cell death program that is distinct from apoptosis, necroptosis and autophagy. It is dependent on iron and reactive oxygen species (ROS) and is characterized by lipid peroxidation. As a novel type of cell death, ferroptosis has distinct properties and recognizing functions involved in physical conditions or various diseases including cancers, neurodegenerative diseases, acute renal failure, etc.

MCE carefully collected a unique collection of 1,177 ferroptosis signaling pathway related compounds with ferroptosis-inducing or -inhibitory activity. MCE Ferroptosis Compound Library is a useful tool to study ferroptosis mechanism as well as related diseases.

Cat. No.	Product Name	Type

HY-D2204

SHP1-IN-1	Fluorescent Dyes
SHP1-IN-1 (compound 5p) is a fluorescent probe for the protein tyrosine phosphatase SHP1 containing the Src homology 2 domain. SHP1-IN-1 has SHP1 inhibitory activity, selectivity for Fe ³⁺ ions and good fluorescence properties. SHP1-IN-1 exhibits aggregation post-quenching (ACQ) effect, good interference immunity and low detection limit (5.55 μM) .

HY-12879G

IWP-4

Fluorescent Dyes

IWP-4 (GMP) is the GMP-grade form of IWP-4 (HY-12879). IWP-4 is a Wnt inhibitor with an IC₅₀ of 25 nM. IWP-4 specifically inhibits casein kinase 1δ/ε (CK1δ/ε), with an IC₅₀ of 1.06 μM against wild-type CK1δ, 1.02 μM against the CK1δ kinase domain, and 7.07 μM against CK1ε; it shows enhanced inhibitory activity against the M82F CK1δ mutant (IC₅₀ = 0.14 μM). IWP-4 is applicable to research related to cancer, Alzheimer's disease (AD), and heart failure .

Cat. No.	Product Name	Type

HY-108749

Olive oil

Maximum Cited Publications

6 Publications Verification

Cropure OL

Biochemical Assay Reagents

Olive oil (Cropure OL) is an oleaginous compound found in the fruit of the Olea europaea tree . Olive oil contains many phenolic components and exerts antioxidant activity. Olive oil exhibits hydroxyl radical scavenging, platelet aggregation inhibition and xanthine oxidase inhibitory activity. Olive oil can promote wound healing and relieve inflammation. Olive oil can be used for the research of inflammation, cancer, metabolic and cardiovascular disease, such as diabetic foot ulcers and inflammatory bowel disease .

HY-W020955

Triphenylphosphinechlorogold

Chloro(triphenylphosphine)gold(I)

Biochemical Assay Reagents

Triphenylphosphinechlorogold (Chloro(triphenylphosphine)gold(I)) is a gold complex, Apoptosis inducer, and catalyst. Triphenylphosphinechlorogold exhibits high LOX inhibitory activity. Triphenylphosphinechlorogold induces cell cycle arrest and apoptosis. Triphenylphosphinechlorogold catalyzes the peroxidation of linoleic acid. A weak interaction exists between Triphenylphosphinechlorogold and DNA. Triphenylphosphinechlorogold displays antiproliferative activity against breast cancer cells .

HY-W016473

Adamantane-carboxylic acid

Biochemical Assay Reagents

Adamantane-carboxylic acid is a compound with inhibitory activity against microorganisms. Although its specific target has not been clearly defined, it can inhibit Gram-positive bacteria and some Gram-negative bacteria. It forms a 1-monoacylglycerol derivative through a direct reaction with glycidol, and exerts its antibacterial effect by mechanisms such as altering the permeability of the bacterial cell membrane. This compound can be used in the research of antibacterial agents in the food and cosmetic industries to reduce harmful microbial flora and extend the shelf life of products .

HY-NP070

Lotus tetragonolobus lectin

LTL

Biochemical Assay Reagents

Lotus tetragonolobus lectin (LTL) is a plant lectin that specifically recognizes and binds to α-L-fucopyranosyl residues, a sugar structure serving as the key terminal glycosyl group of human blood type O antigen (H antigen). Lotus tetragonolobus lectin exerts macrophage migration inhibitory activity in monomeric form. Lotus tetragonolobus lectin labels and identifies renal proximal tubular epithelial cells to evaluate histopathological changes of sepsis-induced acute kidney injury. Lotus tetragonolobus lectin is applicable to studies in glycobiology, immunology and renal pathology .

HY-W007466

Cyclohexane-1,3-dione 1 Publications Verification	Biochemical Assay Reagents
Cyclohexane-1,3-dione is a drug intermediate, and its derivatives can exhibit significant tyrosine kinase inhibitory activity and anti-tumor activity .

HY-W054259

BFMO N,N'-Difurfuryloxamide; N1,N2-Bis(furan-2-ylmethyl)oxalamide	Biochemical Assay Reagents
BFMO (N,N'-Difurfuryloxamide) is an oxamide derivative and a bidentate ligand. BFMO exhibits plant growth regulatory activity and root growth inhibitory activity. BFMO can promote the copper-catalyzed N-arylation reaction between aniline compounds and cyclic secondary amines, realizing the coupling of (hetero) aryl bromides with (hetero) aryl amines and cyclic secondary amines .

HY-W354851

Pisiferic acid	Biochemical Assay Reagents
Pisiferic acid is an antibacterial agent with inhibitory activity against Gram-negative/positive bacteria such as P. vulgaris, S. aureus and B. subtilis. Pisiferic acid can be used to study bacterial infections .

HY-N1731

2′-Hydroxy-5′-methoxyacetophenone

Biochemical Assay Reagents

2'-Hydroxy-5'-methoxyacetophenone is an acetophenone derivative with acaricidal activities. 2'-Hydroxy-5'-methoxyacetophenone attenuates the inﬂammatory response via NF-κB signaling pathway. 2'-Hydroxy-5'-methoxyacetophenone exhibits significant inhibitory activity against α-amylase, collagenase and aldose reductase (AR) with IC₅₀s of 0.928, 3.264 and 20.046 μM, highlighting its potential in combating diabetes. 2'-Hydroxy-5'-methoxyacetophenone exhibits anti-ovarian cancer activity .

HY-D1056B2

Lipopolysaccharides, from Proteus mirabilis

LPS, from bacterial (Proteus mirabilis)

Biochemical Assay Reagents

Lipopolysaccharides, from Proteus mirabilis are lipopolysaccharide endotoxins and TLR-4 activators derived from Proteus mirabilis, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from Proteus mirabilis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Proteus mirabilis is a major pathogen causing urinary tract infections and may also contribute to rheumatoid arthritis. Lipopolysaccharides, from Proteus mirabilis also exhibit potential anti-tumor effects, demonstrating in vivo inhibitory activity against solid tumors such as meningosarcoma and Walker carcinosarcoma .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-W013122

Cholesteryl n-butyrate Cholesteryl butyrate	Biochemical Assay Reagents
Cholesteryl n-butyrate is a cholesterol ester composed of cholesterol and butyrate, two naturally occurring substances. Cholesteryl n-butyrate can be used to synthesize solid lipid nanoparticles (SLNs) with inhibitory activity on the adhesion and migration of colon cancer cells, providing a delivery system for the anticancer drug butyrate .

HY-30139

4-Amino-2-chloropyrimidine	Biochemical Assay Reagents
4-Amino-2-chloropyrimidine is a pyrimidine derivative. 4-Amino-2-chloropyrimidine is a competitive inhibitor for AChE (K_i = 0.18 μM) and BChE (K_i = 1.324 μM). 4-Amino-2-chloropyrimidine fits in the binding pocket of 4BDS. 4-Amino-2-chloropyrimidine has high inhibitory activity on GST enzyme activity (IC₅₀ = 0.037 μM, K_i = 0.047 μM) in vitro .

HY-12879G

IWP-4

Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Area

HY-P4279

Ovalbumin (154-159)	Angiotensin-converting Enzyme (ACE) Cholinesterase (ChE)	Cardiovascular Disease
Ovalbumin (154-159) is a protein fragment consisting of residues 154-159 of chicken ovalbumin. Ovalbumin (154-159) is also a poorly conserved sequence (Thr-Asn-Gly-Ile-Ile-Arg) in the α-subunit of the Torpedo acetylcholine receptor, located within the α150-164 epitope region, and exhibits significant angiotensin-converting enzyme (ACE) inhibitory activity .

HY-P5542

Vicatertide SB-01; Peniel 2000	Factor Xa TGF-beta/Smad	Inflammation/Immunology
Vicatertide (SB-01, Peniel 2000) is a polypeptide with both competitive inhibitory activity against TGF-β1 and selective inhibitory activity against human factor XIa (hFXIa, with a K_a of 80 nM for hFXIa). Vicatertide binds allosterically to the two binding sites of dimeric hFXI/hFXIa, while directly binding to activated TGF-β1, selectively blocking the Smad1/5/8 pathway and maintaining low-level activation of the Smad2 pathway to enhance the synthesis of type Ⅱ collagen and aggrecan. Vicatertide inhibits thrombus formation in arteriovenous thrombosis models, and also reduces thrombus weight and thrombus incidence in mouse lung cancer models. Vicatertide can be used for research on degenerative disc disease and thrombosis-related diseases .

HY-W009118

Fmoc-5-Ava-OH	Amino Acid Derivatives	Others
Fmoc-5-Ava-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize fatty acid-based dimeric peptides with PSD-95 inhibitory activity .

HY-P10202

5-FAM-GpYLPQTV-NH2	STAT	Cancer
5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 can be used in cancer research .

HY-P10447

Plipastatin A1 Fengycin IX; SNA-60-367-3	Phospholipase Fungal	Infection
Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold ^[1][2].

HY-P1547

Somatostatin-25	GHSR	Neurological Disease
Somatostatin-25 is a endogenous neuropeptide hormone that shows inhibitory activity against secretion of growth hormone.

HY-P5107

Low molecular weight protamine LMWP; TDSP5	VEGFR	Cancer
Low molecular weight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. Low molecular weight protamine can inhibit tumor growth and is used in cancer research .

HY-34738

Boc-β-Ala-ol 3-(Boc-amino)-1-propanol	Amino Acid Derivatives	Others
Boc-β-Ala-ol (3-(Boc-amino)-1-propanol) is an alanine derivative with a Boc protecting group at the N-terminus, which can be used to synthesize bioactive peptide mimics, such as Nα-Benzoyl-α-azaornithine phenyl ester, which has trypsin inhibitory activity .

HY-W048722

Fmoc-D-Thi-OH Fmoc-D-2-Thienylalanine	Amino Acid Derivatives	Others
Fmoc-D-Thi-OH (Fmoc-D-2-Thienylalanine) is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize AS-Z-P with thrombin inhibitory activity .

HY-W048730

Fmoc-Phe(4-tBu)-OH	Amino Acid Derivatives	Others
Fmoc-Phe(4-tBu)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize rOicPaPhe(p-Me)-NH(2) with platelet aggregation activation inhibitory activity .

HY-P5016A

CRAMP-18 (mouse) acetate	Antibiotic Fungal Bacterial	Infection Cancer
CRAMP-18 (mouse) acetate is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) acetate has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) acetate has the potential to study antifungal, antibacterial and antitumor .

HY-P10202A

5-FAM-GpYLPQTV-NH2 TFA	STAT	Cancer
5-FAM-GpYLPQTV-NH2 (TFA) is a fluorescently labeled peptide and has STAT3 inhibitory activity. 5-FAM-GpYLPQTV-NH2 (TFA) can be used in cancer research .

HY-P10601A

αs1-CN f(143–149) acetate	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
αs1-CN f(143–149) acetate is an orally active casein-derived peptide sequence. αs1-CN f(143–149) acetate exhibits angiotensin-converting enzyme (ACE) inhibitory activity (IC₅₀=6.58 μM) and antihypertensive activity .

HY-103295A

Lys-[Des-Arg9]Bradykinin TFA	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin TFA, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin TFA has low inhibitory activity on B2 receptors .

HY-P10980

Citrocin	DNA/RNA Synthesis Bacterial	Infection
Citrocin is a potent bacterial RNA polymerase (RNAP) inhibitor. Citrocin shows significant inhibitory activity against Escherichia coli RNAP with an MIC range of 16-125 μM. Citrocin specifically binds to and inhibits RNA polymerase to block bacterial transcription and enters cells mainly through inner membrane protein SbmA. Citrocin is promising for research of Gram-negative bacterial infections, such as enterohemorrhagic E. coli .

HY-P11012

EK1	SARS-CoV	Infection
EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species. EK1 shows substantially improved pan-CoV fusion inhibitory activity. EK1 potently inhibits SARS-CoV-2. EK1 can form a stable six-helix bundle (6HB) structure with both short α-hCoV and long β-hCoV N-terminal heptad repeats .

HY-P11334

Cyanostatin B	Aminopeptidase Phosphatase Angiotensin-converting Enzyme (ACE) DNA/RNA Synthesis	Cancer
Cyanostatin B, a cyanobacterial lipopeptide, is a leucine aminopeptidase M (LAP) inhibitor (IC₅₀ = 12 ng/mL). Cyanostatin B is a weak inhibitor of protein phosphatase (PP2A) and also exhibits weak inhibitory activity against angiotensin-converting enzyme (ACE), with an IC₅₀ value of 130 μg/mL. Cyanostatin B demonstrates both cytotoxic and genotoxic effects on human hepatocytes, although non-toxic to Artemia salina. Cyanostatin B inhibits the proliferation of HepG2 cells, induces DNA single-strand breaks, and causes genomic instability. .

HY-P10159

DJK-5	Bacterial	Infection
Diplacol ia a natural compound from from Mimulus clevelandi and shows potent inhibitory activities against lipopolysaccharide (LPS)-induced nitric oxide production .

HY-P5286

BMAP-27	Bacterial	Infection Cancer
BMAP-27 is an antimicrobial peptide capable of disrupting the membrane integrity of microorganisms. Due to its membrane permeability, MAP-27 has inhibitory activity against both bacteria and cancer cells .

HY-P4810

Polyphemusin II-Derived Peptide T140	CXCR	Infection
Polyphemusin II-Derived Peptide (T140), a CXCR4 inhibitor, shows high inhibitory activity against HIV-1 entry and the inhibitory effect on the binding of an anti-CXCR4 monoclonal antibody (12G5) to CXCR4 .

HY-P2082

[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH	GnRH Receptor	Others
[D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a gonadotropin-releasing hormone (Gn-RH) agonist that has a dose-dependent inhibitory activity on progesterone secretion from cultured human granulosa cells.

HY-P10601

αs1-CN f(143–149)	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
αs1-CN f(143–149) is an orally active casein-derived peptide sequence. αs1-CN f(143–149) exhibits angiotensin-converting enzyme (ACE) inhibitory activity (IC₅₀=6.58 μM) and antihypertensive activity .

HY-P1937

Cyclo(-Met-Pro)	Influenza Virus	Infection
Cyclo(-Met-Pro) is a cyclic dipeptide consisting of the amino acids methionine and proline. Cyclo(-Met-Pro) exhibits weak inhibitory activity against the influenza A virus (H3N2) (5 mM, 2.1% inhibition), while cis-cyclo(Leu-Pro) and cis-cyclo(Phe-Pro) shows significant antiviral activity .

HY-103295

Lys-[Des-Arg9]Bradykinin	Bradykinin Receptor	Metabolic Disease Inflammation/Immunology
Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a K_i of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors .

HY-P11191

AR-23	Bacterial	Infection
AR-23 is a melittin-related antimicrobial peptide that can be isolated from Rana tagoi. AR-23 exhibits broad-spectrum growth inhibitory activity against aerobic bacteria, the opportunistic yeast pathogen Candida albicans and clinical isolates of Methicillin (HY-121544)-resistant Staphylococcus aureus (MRSA). AR-23 can be used for antimicrobial research .

HY-P1681A

GpTx-1 TFA	Sodium Channel	Neurological Disease
GpTx-1 TFA is a peptide-based Na_V1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 TFA demonstrates potent inhibitory activity against the Na_V1.7 channel with an IC₅₀ value of 10 nM, while exhibiting excellent selectivity for Na_V1.4 (IC₅₀ = 0.301 μM) and Na_V1.5 (IC₅₀ = 4.20 μM), showing >20-fold and >950-fold selectivity respectively .

HY-P1681

GpTx-1	Sodium Channel	Neurological Disease
GpTx-1 is a peptide-based Na_V1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the Na_V1.7 channel with an IC₅₀ value of 10 nM, while exhibiting excellent selectivity for Na_V1.4 (IC₅₀ = 0.301 μM) and Na_V1.5 (IC₅₀ = 4.20 μM), showing >20-fold and >950-fold selectivity respectively .

HY-P5642

Retrocyclin-101 RC-101	Bacterial Ser/Thr Protease Influenza Virus HSV SARS-CoV Toll-like Receptor (TLR) Fungal HIV Flavivirus	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) is a synthetic cyclic θ-defensin, a broad-spectrum antimicrobial peptide with anti-pathogen (covering viruses, bacteria and fungi) activity and anti-inflammatory activity. Retrocyclin-101 exhibits significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus and others. Retrocyclin-101 inhibits TLR4 and TLR2-mediated signal transduction and reduces pro-inflammatory cytokine expression .

HY-P10785

Iturin A-2	Bacterial Antibiotic	Infection
Iturin A-2 is a cyclic lipopeptide discovered in B. subtilis and exhibits inhibitory activity against the plant pathogenic fungus P. expansum (MIC = 8 µg/disk). Iturin A-2 is cytotoxic to MCF-7 and BT474 breast cancer cells, as well as HeLa cervical cancer cells, with IC₅₀ values of 66.81, 95.04, and 77.5 µg/mL, respectively. In greenhouse studies, Iturin A-2 at concentrations of 100 and 300 mg/kg Iturin A-2 reduces the lesion area of southern corn leaf blight caused by B. maydis, and in field studies, concentrations of 300 and 500 mg/kg Iturin A-2 reduce the incidence of the disease. Iturin A-2 (12.5 µg/mL) inhibits cell division, but not nuclear division, in isolated fertilized starfish eggs .

HY-P4488

H-Pro-Pro-Gln-OH	Dipeptidyl Peptidase	Others
H-Pro-Pro-Gln-OH is a oligopeptide with excellent dipeptidyl peptidase-IV (DPP-IV) inhibitory activity .

HY-P10542

Dodecapeptide AR71	Peptides	Cancer
Dodecapeptide AR71 is an inhibitor of melanoma inhibitory activity (MIA). Dodecapeptide AR71 can reduce cell migration, reduce metastasis formation, and increase immune response. Dodecapeptide AR71 can be used in research on the treatment of malignant melanoma .

HY-120757

LP-130	Virus Protease	Others
LP-130 is a statin-based inhibitor that is a universal inhibitor with nanomolar inhibitory activity against all tested retroviral proteases. Crystal structure studies of its binding to different retroviral proteases have shown that it can adapt to different active site regions to achieve inhibition.

HY-W748000

Kocurin PM181104; Baringolin	Antibiotic Bacterial	Infection
Kocurin (PM181104) is a thiazolyl cyclic-peptide antibiotic. Kocurin inhibits bacterial growth by impeding bacterial protein biosynthesis during the translation phase. Kocurin has strong inhibitory activity against Gram-positive bacteria, but no activity against fungi and Gram-negative bacteria .

HY-P4095

NoxaBH3	CXCR	Cancer
NoxaBH3 is a cysteine-based cross-linked peptide with increased cell permeability and higher inhibitory activity against Mcl-1. NoxaBH3 binds to the endogenous CXCR4 ligand to produce ubiquitin-Noxabh3 conjugate. NoxaBH3 is then delivered to cancer cells .

HY-P10860

cMCoFx1	Factor Xa	Cardiovascular Disease
cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (K_D: 900 pM) and inhibitory activity (K_i: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic .

HY-P5016

CRAMP-18 (mouse)	Antibiotic Bacterial Fungal	Infection Cancer
CRAMP-18 (mouse) is an antibiotic peptide without hemolytic activity. CRAMP-18 (mouse) has good inhibitory activity against Gram-negative bacteria, such as S. typhimurium and P. aeruginosa. CRAMP-18 (mouse) has the potential to study antifungal, antibacterial and antitumor .

HY-P6177

SGP8	Dipeptidyl Peptidase	Inflammation/Immunology
SGP8 (IAVPGEVA) is an octapeptide produced by hydrolysis of soybean 11S globulin, which has the effects of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway, and has the ability to inhibit non-alcoholic steatohepatitis (NASH) .

HY-P10539

Hp1404	Bacterial	Infection
Hp1404 is a novel cationic antimicrobial peptide. Hp1404 has specific inhibitory activity against Gram-positive bacteria, including Staphylococcus aureus (MRSA) resistant to Laburnetin (HY-N7382). Hp1404 has antimicrobial activity, low toxicity, and is not prone to drug resistance, and can be used in the research of antimicrobial agents .

HY-P10547

Macropin MAC-1 peptide	Bacterial	Infection
Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. Macropin has antibacterial activity against both Gram-positive and Gram-negative bacteria, and also exhibits inhibitory activity against fungi and moderate hemolytic activity against human erythrocytes. Macropin can be used in research on anti-infective therapy .

HY-P5483

Retro-indolicidin	Bacterial	Others
Retro-indolicidin is a biological active peptide. (Reverse peptide of indolicidin (Rev4) is a 13-amino acid residue peptide based on the sequence of indolicidin. Indolicidin, a member of the cathelicidin protein family, is a 13-amino acid residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The synthetic peptide Rev4 has been shown to possess strong antimicrobial as well as protease inhibitory activities in vitro.)

HY-P10570

[Nle20] H4 peptide (16−23)	Histone Methyltransferase	Cancer
[Nle20] H4 peptide (16−23) is a peptide with strong inhibitory activity against histone methyltransferase SETD8 (K_d=0.14 μM), which inhibits SETD8's methylation of histone H4 by competing with SETD8's substrate binding site. [Nle20] H4 peptide (16−23) can be used as a lead compound for anticancer therapy .

HY-P0263R

Dermaseptin (Standard)	Reference Standards Bacterial Fungal Antibiotic	Infection
Kanamycin (sulfate) (Standard) is the analytical standard of Kanamycin (sulfate). This product is intended for research and analytical applications. Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit. Kanamycin sulfate shows good inhibitory activity to both M. tuberculosis (sensitive and drug-resistant ) and K. pneumonia, which can be used in studies of tuberculosis and pneumonia .

HY-P3492

SARS-CoV-2-IN-34	SARS-CoV	Infection
SARS-CoV-2-IN-34 (S-20-1) is a blood brain barrier penetrable pan-coronavirus (CoV) fusion inhibitor with broad-spectrum inhibitory activity. SARS-CoV-2-IN-34 effectively inhibits infection by pseudotyped and authentic SARS-CoV-2, and pseudotyped variants of concern (VOCs). SARS-CoV-2-IN-34 shows high affinity to RBD in S1 and HR1 domain in S2 of SARS-CoV-2 S protein. SARS-CoV-2-IN-34 can be used for the research of infection .

HY-P5439

Epsilon-V1-2, Cys-conjugated	PKC MARCKS	Others
Epsilon-V1-2, Cys-conjugated is a biological active peptide. (This peptide is the εPKC specific inhibitor. Its inhibitory activity is based on εPKC translocation and MARCKS phosphorylation. This peptide interferes with εPKC interaction with the anchoring protein εRACK. This peptide contains a cysteine residue added to the C-terminus for potential S-S bond formation with a carrier protein.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P10434

BRC4wt BRC4 repeat motif	Peptides	Cancer
BRC4wt (BRC4 repeat motif) is part of the BRACA2 tumor suppressor protein, which exhibits inhibitory activity against interaction of the BRACA2 protein with RAD51, and is involved in the repair of DNA damage .

HY-P11740

VYPFPGPIHN	Angiotensin-converting Enzyme (ACE) Drug Intermediate	Others
VYPFPGPIHN is a precursor peptide of β-casomorphin (HY-P0179) and also an ACE inhibitor (IC₅₀ = 123 μM). VYPFPGPIHN resists hydrolysis by peptidases associated with intestinal cell monolayers, maintaining structural integrity and ACE inhibitory activity. VYPFPGPIHN is not extensively taken up or transported by differentiated intestinal cell monolayers .

HY-P11399

Tachyplesin-3	Bacterial Fungal	Infection
Tachyplesin-3 is a broad-spectrum cationic antimicrobial peptide. Tachyplesin-3 has inhibitory activity against Gram-positive bacteria, Gram-negative bacteria, fungi and enveloped viruses. Tachyplesin-3 binds to bacterial membrane lipopolysaccharides through positive charges, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin-3 interferes with bacterial adhesion and aggregation, prevents biofilm formation, and has a synergistic effect when used in combination with Piperacillin (HY-B1923) - Tazobactam (HY-B1418) (TZP) .

HY-P10611

[D-Ser14]-Humanin	Amyloid-β	Neurological Disease
[D-Ser14]-Humanin is a bioactive peptide in which the Ser14 residue of Humanin (HY-P1928) is changed from L-form to D-form. [D-Ser14]-Humanin has potent inhibitory activity against the fibrillation of amyloid-β. Humanin (HY-P1928) inhibits the aging-related death of various cells caused by amyloid fibrils and oxidative stress, and [D-Ser14]-Humanin has better cell protection activity than Humanin (HY-P1928). [D-Ser14]-Humanin can be used in the study of Alzheimer's disease .

HY-P5642A

Retrocyclin-101 TFA RC-101 TFA	HIV SARS-CoV Influenza Virus Flavivirus HSV Bacterial Fungal Toll-like Receptor (TLR) Ser/Thr Protease	Infection Inflammation/Immunology
Retrocyclin-101 (RC-101) TFA is an artificially synthesized, cyclic-structured θ-defensin, a broad-spectrum agent with antimicrobial (covering viruses, bacteria, and fungi) activity and anti-inflammatory activity. Retrocyclin-101 TFA can inhibit the serine protease activity of ZIKV NS2B-NS3, with an IC₅₀ of 7.20 μM. Retrocyclin-101 TFA has significant inhibitory activity against HIV, SARS-CoV-2, flaviviruses, influenza viruses, HSV-1/2, Staphylococcus aureus, etc. Retrocyclin-101 TFA inhibits the signal transduction mediated by TLR4 and TLR2, reducing the expression of pro-inflammatory cytokines .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990068

Perenostobart SRF617	NTPDase	Inflammation/Immunology Cancer
Perenostobart (SRF617) is a human IgG4 antibody with inhibitory activity against CD39 ATPase. Perenostobart inhibits CD39-mediated hydrolysis of extracellular ATP to AMP, with IC₅₀ values of 1.9 nM (HEK293 OE cells), 0.7 nM (MOLP-8 cells), and 1.2 nM (RBC-lysed whole blood). Perenostobart enhances CD4 ⁺ T-cell proliferation, promotes dendritic cell maturation, and boosts inflammasome activation in macrophages in the presence of ATP. Perenostobart demonstrates significant single-agent anti-tumor efficacy in MOLP-8 and H520 xenograft models. Perenostobart can be used for the study of cancer .

HY-P990740

Fanastomig EMB-02	PD-1/PD-L1 LAG-3	Inflammation/Immunology Cancer
Fanastomig (EMB-02) is a bispecific antibody against PD-1/LAG3. Fanastomig exhibits potential immune checkpoint inhibitory activity and antineoplastic activity .

HY-P991900

LY3541860	CD19	Inflammation/Immunology
LY3541860 is a selective anti-CD19 antibody that both binds human CD19 with high affinity and selectively binds human B cells (K_d values: 76.8 pM and 94.5 nM for humans and cynomolgus monkeys, respectively). LY3541860 inhibits CpG-induced CD69 expression (IC₅₀ = 0.006 nM). LY3541860 exhibits potent B cell inhibitory activities. LY3541860 can inhibit both BCR- and TLR-induced human B cell activation. LY3541860 can be used for the research of autoimmune diseases .

HY-P992356

GENA-104A16	Topoisomerase	Cancer
GENA-104A16 is a humanized monoclonal antibody targeting CNTN4, with multiple functions including immunostimulation, cytotoxicity and immunoregulation. By binding to CNTN4, GENA-104A16 blocks its interaction with APP, thereby restoring T cell function, inducing tumor cell death and regulating tumor-infiltrating immune cell populations. GENA-104A16 also exerts topoisomerase I inhibitory activity via the payload Exatecan (HY-13631). GENA-104A16 can be used in research related to colon cancer liver metastasis and other CNTN4-expressing solid tumors .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	CHO (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70846

	MIA Protein, Human (His) Melanoma-Derived Growth Regulatory Protein; Melanoma Inhibitory Activity Protein; MIA	Human	E. coli
	MIA proteins exhibit significant growth inhibitory effects on melanoma cells in vitro, extending their effects to various neuroectodermal tumors such as gliomas. In addition to playing an inhibitory role in cell growth, MIA proteins are also involved in molecular interactions, interacting with FASLG and TMIGD2. MIA Protein, Human (His) is the recombinant human-derived MIA protein, expressed by E. coli , with C-6*His labeled tag.

HY-P70846A

	MIA Protein, Human (N-His) Melanoma-Derived Growth Regulatory Protein; Melanoma Inhibitory Activity Protein; MIA	Human	E. coli
	MIA proteins exhibit significant growth inhibitory effects on melanoma cells in vitro, extending their effects to various neuroectodermal tumors such as gliomas. In addition to playing an inhibitory role in cell growth, MIA proteins are also involved in molecular interactions, interacting with FASLG and TMIGD2. MIA Protein, Human (N-His) is the recombinant human-derived MIA protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7393

	Otoraplin/OTOR Protein, Human (CHO) rHuOTOR; Fibrocyte-derived protein; Melanoma inhibitory activity-like protein; OTOR; MIAL	Human	CHO
	Otoraplin/OTOR Protein, Human (CHO) is a protein encoded by OTOR gene, is homologous to the protein encoded by CDRAP/MIA, and may acts in cartilage development and maintenance.

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Cat. No.	Product Name		Classification

HY-179403

KRASG12C IN-17		Alkynes
KRASG12C IN-17 is an orally active covalent KRAS ^G12C inhibitor, showing strong inhibitory activity in KRAS ^G12C-mutant cancer cells (NCI-H23 IC₅₀ = 0.7 nM; NCI-H358 IC₅₀ = 0.5 nM). KRASG12C IN-17 covalently and irreversibly binds to KRAS ^G12C with > 96% modification efficiency in both GDP-bound and GMPPNP-bound conformations. KRASG12C IN-17 can be used for studies of KRAS-driven cancers, including colorectal cancer .

HY-176502

FKBP12 ligand-3		Alkynes
FKBP12 ligand-3 (compound dj) is a high-affinity ligand targeting FKBP12. FKBP12 ligand-3 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-3 can be used for selective cancer research based on differences in intracellular presenter protein levels .

HY-176501

FKBP12 ligand-2		Alkynes
FKBP12 ligand-2 (compound d) is a high affinity ligand targeting FKBP12. FKBP12 ligand-2 can be used to selectively enhance the binding of heterobifunctional molecules to BRD4, enriching the drug intracellularly through the "CellTrap" effect to form a ternary complex of FKBP12-ligand-BRD4. This ternary complex has inhibitory activity against BRD4, thereby inhibiting the expression of BRD4 target genes (such as MYC) and inducing tumor cell death. FKBP12 ligand-2 can be used for selective cancer research based on differences in intracellular presenter protein levels .

HY-149057

Neuraminidase-IN-12		Azide
NDV-IN-1 is an antiviral agent with high neuraminidase inhibitory activity. NDV-IN-1 exhibits in vitro inhibitory activity against Newcastle disease virus (NDV). NDV-IN-1 significantly inhibits NDV infection of Vero cells by preventing the release of virus particles from infected cells . Neuraminidase-IN-12 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-179232

ERα antagonist 2		Tetrazine
ERα antagonist 2 (Compound 5b) is an ER-α antagonist with an IC₅₀ value of 1729 nM. ERα antagonist 2 exhibits significant inhibitory activity against breast cancer cell lines, and is still effective against ER-negative cells (MDA-MB-231), suggesting the existence of ER-independent pathways. ERα antagonist 2 can be used for the study of breast cancer .

HY-162356

PD-L1-IN-4		Azide
PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC₅₀ = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC₅₀ = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer .

HY-125387

TOP1210		Alkynes
TOP1210 is a narrow-spectrum tyrosine kinase inhibitor with potent inhibitory activity against P38α, Src, and Syk kinases. TOP1210 effectively reduced proinflammatory cytokines released by peripheral blood monocytes, primary macrophages, HT29 cells, inflammatory cells in ulcerative colitis (UC) biopsies, and myofibroblasts isolated from inflamed colonic UC mucosa. TOP1210 showed significant anti-inflammatory effects in cell experiments and UC biopsies, superior to some selective kinase inhibitors. The multi-kinase inhibition of TOP1210 provides the possibility of obtaining a wider range of therapeutic effects, especially in the regulation of autoimmune responses .

HY-160601

Anticancer agent 294		Alkynes
Anticancer agent 294 (Example 2) is an anticancer agent that has inhibitory activity against apoptosis inhibitor protein 1 (cIAP1) with an IC₅₀ of 15 nM .

HY-N16526

Juncatrin B		Alkynes
Juncatrin B is a type of dihydrophenanthrene compound. Juncatrin B exhibits inhibitory activity against both Methicillin (HY-121544)-sensitive Staphylococcus aureus (MSSA) and Methicillin-resistant Staphylococcus aureus (MRSA). Juncatrin B can inhibit the formation of biofilms in MSSA and MRSA. Juncatrin B has no significant activity against Gram-negative bacteria. Juncatrin B can be used in the research of anti-Staphylococcus aureus .

HY-159564

iNOS/COX-2-IN-3		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

HY-115824

7ETMC		Alkynes
7ETMC is a cytochrome P450 inhibitor with selective inhibition of human cytochrome P450s 1A1 and 1A2. 7ETMC has inhibitory effects on P450s 1A1 and 1A2 with IC?? values of 0.46μM and 0.50μM, respectively, within the first six minutes, and has no inhibitory activity against P450s 2A6 and 2B1. Except for 7-ethynyl-3-methyl-4-phenylcoumarin, the remaining inhibitors show mechanism-based inhibition of P450s 1A1 and 1A2.

Cat. No.	Product Name		Classification

HY-N0717

L-Valine 5 Publications Verification (S)-Valine		Freeze-drying Protective Agents Solubilizing Agents
L-Valine ((S)-Valine) is a nonlinear semiorganic material. L-Valine causes lipid peroxidation and accumulation of malondialdehyde (MDA), exhibits inhibitory activity against cyanobacteria. L-Valine inhibits multidrug-resistant bacteria through activation of PI3K/Akt signaling pathway and inhibition of arginase .

HY-108749

Olive oil Maximum Cited Publications 6 Publications Verification Cropure OL		Solvents
Olive oil (Cropure OL) is an oleaginous compound found in the fruit of the Olea europaea tree . Olive oil contains many phenolic components and exerts antioxidant activity. Olive oil exhibits hydroxyl radical scavenging, platelet aggregation inhibition and xanthine oxidase inhibitory activity. Olive oil can promote wound healing and relieve inflammation. Olive oil can be used for the research of inflammation, cancer, metabolic and cardiovascular disease, such as diabetic foot ulcers and inflammatory bowel disease .

HY-132610A

Givosiran sodium 1 Publications Verification ALN-AS1 sodium		siRNAs siRNA drugs
Givosiran (ALN-AS1) sodium is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran sodium downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran sodium demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran sodium can be used for the research of acute hepatic porphyria (AHP) .

HY-132610

Givosiran 1 Publications Verification ALN-AS1		siRNAs siRNA drugs
Givosiran (ALN-AS1) is a small interfering RNA that targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA. Givosiran downregulates ALAS1 mRNA and prevents accumulation of neurotoxic δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) levels. Givosiran demonstrates potent inhibitory activity against ALAS1 in mouse, rat, and cynomolgus monkey models. Givosiran can be used for the research of acute hepatic porphyria (AHP) .

HY-N0538

Xylitol Xylite		Fillers
Xylitol can be classified as a polyol and sugar alcohol, exhibiting inhibitory activity on cancer cell proliferation. It induces autophagy (Autophagy) and cell death in A549 cells by activating the autophagy signaling pathway, as evidenced by the increased expression of LC3-II and Atg5-Atg12 upon Xylitol treatment. Additionally, Xylitol inhibits acetaldehyde production by Candida species, thereby reducing their carcinogenic potential. In vivo, Xylitol induces alterations in the gut microbiota of mice, which may enhance cholesterol accumulation and upregulate hepatic ChREBP, while also slowing tumor growth in the B16F10 melanoma C57BL/6 mouse model .

HY-W784565

5-Fluorouridine 5'-phosphate		Nucleotide Analogs Uracil Nucleotide
5-Fluorouridine 5'-phosphate is an ODCase (orotidine-5′-monophosphate decarboxylase) inhibitor, with a K_i value of 98 µM for human ODCase and a K_i value of 645 µM for Methanobacterium ODCase. 5-Fluorouridine 5'-phosphate exhibits inhibitory activity against leukemia and lymphoma cell lines and can be used in cancer research .

HY-W570886

2'-O-MOE-U		Phosphoramidites Uracil
2'-O-MOE-U is a nucleic acid modification group (Phosphoramidite) with 3'-exonuclease inhibitory activity. 2'-O-MOE-U also exhibits gene silencing activity and double-stranded oligonucleotide stability. By forming steric interactions with 3'-exonuclease residues, 2'-O-MOE-U anchors the 3'-end of the siRNA guide strand in the hAgo2 PAZ domain, thereby regulating double-stranded thermal stability and enhancing base-pairing specificity. 2'-O-MOE-U does not induce IFNα production, can be incorporated at multiple sites of siRNA to enhance RNAi activity, and produces a synergistic effect with 2'-F modification. 2'-O-MOE-U has been widely used in studies related to breast cancer and other diseases .

HY-W013122

Cholesteryl n-butyrate Cholesteryl butyrate		Cholesterol
Cholesteryl n-butyrate is a cholesterol ester composed of cholesterol and butyrate, two naturally occurring substances. Cholesteryl n-butyrate can be used to synthesize solid lipid nanoparticles (SLNs) with inhibitory activity on the adhesion and migration of colon cancer cells, providing a delivery system for the anticancer drug butyrate .

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