FGFR-IN-23
FGFR-IN-23 (Compound 9p) is a covalent pan FGFR inhibitor with IC50s of 14, 4.2, 5 and 220 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-23 also has potent inhibitory activity against gatekeeper mutants, such as FGFR1V561M and FGFR3V555M. FGFR-IN-23 suppresses the activation of FGFR-mediated signaling and induces apoptosis. FGFR-IN-23 shows significant antitumor efficacy in RT112 xenograft mouse models. FGFR-IN-23 can be used for cancers and its drug resistance research.
For research use only. We do not sell to patients.
- Formula: C27H28N8O2
- Molecular Weight:496.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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FGFR1 14 nM (IC50) |
FGFR2 4.2 nM (IC50) |
FGFR3 5 nM (IC50) |
FGFR4 220 nM (IC50) |
Chemical Information
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Molecular Weight 496.56
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Formula C27H28N8O2
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SMILES
C=CC(NC1=CC2=C(C=C1)C(C3=CNC4=NC=C(C5=CN(CCN6CCOCC6)N=C5)N=C43)=CN2C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FGFR-IN-23 Related Classifications
HY-178059 Related Classifications
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