SENP2-IN-1
Based on 1 Customer Validation
SENP2-IN-1 (compound 77) is a selective SENP2 inhibitor. SENP2-IN-1 shows inhibitory activities with IC50s of 1.3, 0.69 and 22.7 μM for SENP1, SENP2 and SENP5, respectively. SENP2-IN-1 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 2986220-46-4
- Formula: C32H29N3O5S2
- Molecular Weight:599.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 1.3 μM (SENP1), 0.69 μM (SENP2), 22.7 μM (SENP5)[1]
SENP2-IN-1 (0.78-100 μM; 10 min) inhibits activities of SENP1, SENP2 and SENP5 with IC50 values of 1.3, 0.69 and 22.7 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2986220-46-4
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Appearance Solid
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Molecular Weight 599.72
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Formula C32H29N3O5S2
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Color Light yellow to yellow
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SMILES
O=C(OCC)CNC1=CC=C2C(C(OCC3=CC=CC=C3)=C(C(NCC4=CC=CC(NC(C5=CC=CS5)=O)=C4)=O)S2)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (166.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.17 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6674 mL | 8.3372 mL | 16.6744 mL | 41.6861 mL |
| 5 mM | 0.3335 mL | 1.6674 mL | 3.3349 mL | 8.3372 mL | |
| 10 mM | 0.1667 mL | 0.8337 mL | 1.6674 mL | 4.1686 mL | |
| 15 mM | 0.1112 mL | 0.5558 mL | 1.1116 mL | 2.7791 mL | |
| 20 mM | 0.0834 mL | 0.4169 mL | 0.8337 mL | 2.0843 mL | |
| 25 mM | 0.0667 mL | 0.3335 mL | 0.6670 mL | 1.6674 mL | |
| 30 mM | 0.0556 mL | 0.2779 mL | 0.5558 mL | 1.3895 mL | |
| 40 mM | 0.0417 mL | 0.2084 mL | 0.4169 mL | 1.0422 mL | |
| 50 mM | 0.0333 mL | 0.1667 mL | 0.3335 mL | 0.8337 mL | |
| 60 mM | 0.0278 mL | 0.1390 mL | 0.2779 mL | 0.6948 mL | |
| 80 mM | 0.0208 mL | 0.1042 mL | 0.2084 mL | 0.5211 mL | |
| 100 mM | 0.0167 mL | 0.0834 mL | 0.1667 mL | 0.4169 mL |
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