JTK-109
Based on 1 Customer Validation
JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC50 value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) .
For research use only. We do not sell to patients.
- Purity: 98.68%
- CAS No.: 480462-62-2
- Formula: C37H33ClFN3O4
- Molecular Weight:638.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.017μM (NS5B)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-5-2 | CC50 |
>20 μM
Compound: 1
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Cytotoxicity against Huh-5-2 cells
Cytotoxicity against Huh-5-2 cells
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[PMID: 17383878] |
| Huh-5-2 | CC50 |
25 μM
Compound: 10n
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Viability of Huh5-2 cells by MTT assay
Viability of Huh5-2 cells by MTT assay
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[PMID: 16854079] |
| Huh-5-2 | EC50 |
0.32 μM
Compound: 1
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Antiviral activity against HCV in Huh-5-2 cells by replicon assay
Antiviral activity against HCV in Huh-5-2 cells by replicon assay
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[PMID: 17383878] |
| Huh-5-2 | EC50 |
0.32 μM
Compound: 10n
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Inhibition of HCV subgenomic RNA replication in Huh5-2 cells after 48 hrs by replicon assay
Inhibition of HCV subgenomic RNA replication in Huh5-2 cells after 48 hrs by replicon assay
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[PMID: 16854079] |
Chemical Information
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CAS No. 480462-62-2
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Appearance Solid
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Molecular Weight 638.13
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Formula C37H33ClFN3O4
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Color White to off-white
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SMILES
O=C(C1=CC=C2C(N=C(C3=CC=C(OCC4=CC(N5C(CCC5)=O)=CC=C4C6=CC=C(Cl)C=C6)C=C3F)N2C7CCCCC7)=C1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Hirashima S, et al. Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3181-6. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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