480462-62-2
480462-62-2
Chemical Structure
JTK-109
- CAS. Nr.: 480462-62-2
- Formula:C37H33ClFN3O4
- Molecular Weight:638.13
IUPAC Name: 2-(4-((4'-chloro-4-(2-oxopyrrolidin-1-yl)-[1,1'-biphenyl]-2-yl)methoxy)-2-fluorophenyl)-1-cyclohexyl-1H-benzo[d]imidazole-5-carboxylic acid
InChIKey: NIBYCXOKANETJM-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(N=C(C3=CC=C(OCC4=CC(N5C(CCC5)=O)=CC=C4C6=CC=C(Cl)C=C6)C=C3F)N2C7CCCCC7)=C1)O
Biological Activity: JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC50 value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) [1].
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JTK-109 | 98.68% | JTK-109 is a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase. JTK-109 has NS5B inhibitory activity with IC50 value of 0.017μM. JTK-109 can be used for the research of hepatitis C virus (HCV) . | ||||||||||||||||||||
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References
- [1]. Hirashima S, et al. Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety. Bioorg Med Chem Lett. 2007 Jun 1;17(11):3181-6. [Content Brief]
