LSD1-IN-23
LSD1-IN-23 is a competitive/non-competitive mixed inhibitor of lysine specific demethylase 1 (LSD1). LSD1-IN-23 has LSD1 inhibitory activity with an IC50 value of 0.58 μM. LSD1-IN-23 can be used for the research of neuroblastoma (NB).
For research use only. We do not sell to patients.
- CAS No.: 3033660-66-8
- Formula: C19H13BrClN5O2S
- Molecular Weight:490.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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KDM1/LSD1 0.58 μM (IC50) |
In Vitro
LSD1-IN-23 (Compound 48) (0-100 μM) exhibits effective LSD1 inhibitory activity with an IC50 value of 0.58 μM[1].
LSD1-IN-23 (0.005, 0.037, 0.111, 0.333 μM; 72 h) significantly increases global H3K4Me2 in NB cells[1].
LSD1-IN-23 (0.1 μM; 24 h) has synergistic effect combination treatment with Bortezomib in NB cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:CHP134 and IMR32 cells
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Concentration:0.1 μM
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Incubation Time:24 h
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Result:Enhanced cytotoxicity in MYCN-amplified NB cells combination treatment of bortezomib with compound 48.
Chemical Information
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CAS No. 3033660-66-8
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Molecular Weight 490.76
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Formula C19H13BrClN5O2S
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SMILES
O=S(NC(C=CC(Br)=C1)=C1C2=NNN=N2)(C3=CC=C(C=C3)C4=CC=C(C=C4)Cl)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LSD1-IN-23 Related Classifications
HY-152032 Related Classifications
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