HDAC-IN-96
HDAC-IN-96 (Compound 3f) is a selective HDAC1/2 inhibitor with IC50 values of 457.1 and 433.7 nM. HDAC-IN-96 has strong inhibitory activity against multiple hematological tumor cells (RS4;11, K562, RPMI-8226, U266), with IC50 values ranging from 2.11 to 5.35 μM. HDAC-IN-96 can induce cancer cells apoptosis and S phase arrest. HDAC-IN-96 can be used for the research of cancer, such as acute lymphoblastic leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3055552-13-8
- Formula: C27H22FN5O5
- Molecular Weight:515.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
HDAC2 433.7 nM (IC50) |
HDAC1 457.1 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
5.35 μM
Compound: 3f
|
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 37995564] |
| RPMI-8226 | IC50 |
3.72 μM
Compound: 3f
|
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 37995564] |
| RS4-11 | IC50 |
2.11 μM
Compound: 3f
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Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 37995564] |
| U-266 | IC50 |
2.94 μM
Compound: 3f
|
Antiproliferative activity against human U-266 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human U-266 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
|
[PMID: 37995564] |
Chemical Information
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CAS No. 3055552-13-8
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Molecular Weight 515.49
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Formula C27H22FN5O5
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SMILES
O=C(C1=CC=C(C=C1)CNC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)NC5=CC=C(C=C5N)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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