HDAC-IN-96
HDAC-IN-96 (Compound 3f) is a selective HDAC1/2 inhibitor with IC50 values of 457.1 and 433.7 nM. HDAC-IN-96 has strong inhibitory activity against multiple hematological tumor cells (RS4;11, K562, RPMI-8226, U266), with IC50 values ranging from 2.11 to 5.35 μM. HDAC-IN-96 can induce cancer cells apoptosis and S phase arrest. HDAC-IN-96 can be used for the research of cancer, such as acute lymphoblastic leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3055552-13-8
- 分子式: C27H22FN5O5
- 分子量:515.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
HDAC2 433.7 nM (IC50) |
HDAC1 457.1 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
5.35 μM
Compound: 3f
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Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human K562 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
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[PMID: 37995564] |
| RPMI-8226 | IC50 |
3.72 μM
Compound: 3f
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Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human RPMI-8226 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
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[PMID: 37995564] |
| RS4-11 | IC50 |
2.11 μM
Compound: 3f
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Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
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[PMID: 37995564] |
| U-266 | IC50 |
2.94 μM
Compound: 3f
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Antiproliferative activity against human U-266 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
Antiproliferative activity against human U-266 cells assessed as cell growth inhibition incubated for 48 hrs by CCK-8 assay
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[PMID: 37995564] |
化学情報
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CAS 番号 3055552-13-8
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分子量 515.49
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分子式 C27H22FN5O5
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SMILES
O=C(C1=CC=C(C=C1)CNC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)NC5=CC=C(C=C5N)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
HDAC-IN-96 関連分類
HY-177768 関連分類
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