3055552-13-8
Chemical Structure
HDAC-IN-96
- CAS No.: 3055552-13-8
- Formula:C27H22FN5O5
- Molecular Weight:515.49
SMILES: O=C(C1=CC=C(C=C1)CNC2=CC=CC(C(N3C4CCC(NC4=O)=O)=O)=C2C3=O)NC5=CC=C(C=C5N)F
Biological Activity: HDAC-IN-96 (Compound 3f) is a selective HDAC1/2 inhibitor with IC50 values of 457.1 and 433.7 nM. HDAC-IN-96 has strong inhibitory activity against multiple hematological tumor cells (RS4;11, K562, RPMI-8226, U266), with IC50 values ranging from 2.11 to 5.35 μM. HDAC-IN-96 can induce cancer cells apoptosis and S phase arrest. HDAC-IN-96 can be used for the research of cancer, such as acute lymphoblastic leukemia[1].
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HDAC-IN-96 | HDAC-IN-96 (Compound 3f) is a selective HDAC1/2 inhibitor with IC50 values of 457.1 and 433.7 nM. HDAC-IN-96 has strong inhibitory activity against multiple hematological tumor cells (RS4;11, K562, RPMI-8226, U266), with IC50 values ranging from 2.11 to 5.35 μM. HDAC-IN-96 can induce cancer cells apoptosis and S phase arrest. HDAC-IN-96 can be used for the research of cancer, such as acute lymphoblastic leukemia. | |||||||||||||||||||||
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Keywords
