2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. BBT-176

BBT-176 is an orally effective EGFR inhibitor. BBT-176 has inhibitory activity against multiple EGFR C797S mutant cell lines. BBT-176 is commonly used in cancer research.

For research use only. We do not sell to patients.

BBT-176

BBT-176 Chemical Structure

CAS No. : 2254805-44-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

BBT-176 Related Antibodies

Top Publications Citing Use of Products

View All EGFR Isoform Specific Products:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

BBT-176 is an orally effective EGFR inhibitor. BBT-176 has inhibitory activity against multiple EGFR C797S mutant cell lines. BBT-176 is commonly used in cancer research[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
27 nM
Compound: 8; BBT-176
Inhibition of cell growth in mouse BaF3 cells harboring EGFR del19/T790M/C797S mutant incubated for 72 hrs by fluorescence based assay
Inhibition of cell growth in mouse BaF3 cells harboring EGFR del19/T790M/C797S mutant incubated for 72 hrs by fluorescence based assay
[PMID: 38908104]
Clinical Trial
Molecular Weight

601.16

Formula

C28H37ClN8O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC)=NC=C2Cl)C=CC=C1)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (83.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6635 mL 8.3173 mL 16.6345 mL
5 mM 0.3327 mL 1.6635 mL 3.3269 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.98%

SDS (251 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6635 mL 8.3173 mL 16.6345 mL 41.5863 mL
5 mM 0.3327 mL 1.6635 mL 3.3269 mL 8.3173 mL
10 mM 0.1663 mL 0.8317 mL 1.6635 mL 4.1586 mL
15 mM 0.1109 mL 0.5545 mL 1.1090 mL 2.7724 mL
20 mM 0.0832 mL 0.4159 mL 0.8317 mL 2.0793 mL
25 mM 0.0665 mL 0.3327 mL 0.6654 mL 1.6635 mL
30 mM 0.0554 mL 0.2772 mL 0.5545 mL 1.3862 mL
40 mM 0.0416 mL 0.2079 mL 0.4159 mL 1.0397 mL
50 mM 0.0333 mL 0.1663 mL 0.3327 mL 0.8317 mL
60 mM 0.0277 mL 0.1386 mL 0.2772 mL 0.6931 mL
80 mM 0.0208 mL 0.1040 mL 0.2079 mL 0.5198 mL
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BBT-176 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BBT-1762254805-44-0BBT176BBT 176EGFREpidermal growth factor receptorErbB-1HER1mutantcancerInhibitorinhibitorinhibit

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