BBT-176
Based on 1 Customer Validation
BBT-176 is an orally effective EGFR inhibitor. BBT-176 has inhibitory activity against multiple EGFR C797S mutant cell lines. BBT-176 is commonly used in cancer research.
For research use only. We do not sell to patients.
- Purity: 98.98%
- CAS No.: 2254805-44-0
- Formula: C28H37ClN8O3S
- Molecular Weight:601.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All EGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
27 nM
Compound: 8; BBT-176
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Inhibition of cell growth in mouse BaF3 cells harboring EGFR del19/T790M/C797S mutant incubated for 72 hrs by fluorescence based assay
Inhibition of cell growth in mouse BaF3 cells harboring EGFR del19/T790M/C797S mutant incubated for 72 hrs by fluorescence based assay
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[PMID: 38908104] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2254805-44-0
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Appearance Solid
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Molecular Weight 601.16
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Formula C28H37ClN8O3S
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Color White to off-white
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SMILES
O=S(NC1=C(NC2=NC(NC3=CC=C(N4CCC(CC4)N5CCN(CC5)C)C=C3OC)=NC=C2Cl)C=CC=C1)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (83.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6635 mL | 8.3173 mL | 16.6345 mL | 41.5863 mL |
| 5 mM | 0.3327 mL | 1.6635 mL | 3.3269 mL | 8.3173 mL | |
| 10 mM | 0.1663 mL | 0.8317 mL | 1.6635 mL | 4.1586 mL | |
| 15 mM | 0.1109 mL | 0.5545 mL | 1.1090 mL | 2.7724 mL | |
| 20 mM | 0.0832 mL | 0.4159 mL | 0.8317 mL | 2.0793 mL | |
| 25 mM | 0.0665 mL | 0.3327 mL | 0.6654 mL | 1.6635 mL | |
| 30 mM | 0.0554 mL | 0.2772 mL | 0.5545 mL | 1.3862 mL | |
| 40 mM | 0.0416 mL | 0.2079 mL | 0.4159 mL | 1.0397 mL | |
| 50 mM | 0.0333 mL | 0.1663 mL | 0.3327 mL | 0.8317 mL | |
| 60 mM | 0.0277 mL | 0.1386 mL | 0.2772 mL | 0.6931 mL | |
| 80 mM | 0.0208 mL | 0.1040 mL | 0.2079 mL | 0.5198 mL |
BBT-176 Related Classifications
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