2. PROTAC Epigenetics Apoptosis
  3. PROTACs Histone Methyltransferase IAP
  4. PROTAC EZH2 Degrader-21

PROTAC EZH2 Degrader-21 is an EZH2 degrader developed based on PROTAC technology. PROTAC EZH2 Degrader-21 induces the degradation of the target protein EZH2 via specific recruitment of the cIAP E3 ligase. PROTAC EZH2 Degrader-21 exhibits significant inhibitory activity in a variety of lymphoma cell lines. PROTAC EZH2 Degrader-21 can be used for research on the pathogenesis of lymphoma.
(Pink: EZH2 ligand (HY-147230); Blue: cIAP ligand (HY-137159); Black: linker).

For research use only. We do not sell to patients.

PROTAC EZH2 Degrader-21

PROTAC EZH2 Degrader-21 Chemical Structure

CAS No. : 3093642-36-2

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PROTAC EZH2 Degrader-21 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All Histone Methyltransferase Isoform Specific Products:

View All Isoforms
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

View All IAP Isoform Specific Products:

View All Isoforms
cIAP cIAP-1 cIAP-2 XIAP

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Description

PROTAC EZH2 Degrader-21 is an EZH2 degrader developed based on PROTAC technology. PROTAC EZH2 Degrader-21 induces the degradation of the target protein EZH2 via specific recruitment of the cIAP E3 ligase. PROTAC EZH2 Degrader-21 exhibits significant inhibitory activity in a variety of lymphoma cell lines. PROTAC EZH2 Degrader-21 can be used for research on the pathogenesis of lymphoma[1]. (Pink: EZH2 ligand (HY-147230); Blue: cIAP ligand (HY-137159); Black: linker).

IC50 & Target

EZH2

 

cIAP

 

In Vitro

PROTAC EZH2 Degrader-21 (compound 55) inhibits proliferation of SU-DHL-6 and HBL-1 diffuse large B-cell lymphoma cells with an IC50 range of 10.81-14.33 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC EZH2 Degrader-21 Related Antibodies
Molecular Weight

1085.34

Formula

C60H80N10O9
CAS No.
SMILES

CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)C(CCC5=CN(N=N5)CCCC(N[C@@H]([C@H](O)C(N[C@@H](CC(C)C)C(OC)=O)=O)CC6=CC=CC=C6)=O)=O)=CC(C(NCC7=C(C=C(NC7=O)C)C)=O)=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC EZH2 Degrader-21 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EZH2 Degrader-213093642-36-2PROTACsHistone MethyltransferaseIAPlymphoma cellsHBL-1 cellsEZH2cIAP E3 ligasediffuse large B-cell lymphoma cellsSU-DHL-6 cellsInhibitorinhibitorinhibit

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