2. Metabolic Enzyme/Protease
  3. Isocitrate Dehydrogenase (IDH)
  4. ML309

ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of α-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer.

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ML309

ML309 Chemical Structure

CAS No. : 1355446-05-7

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Description

ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of α-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 μM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer[1].

IC50 & Target[1]

R132H IDH1

96 nM (IC50)

Molecular Weight

484.56

Formula

C29H29FN4O2
CAS No.
SMILES

O=C(N(C(C1=CC=CC=C1C)C(NC2CCCC2)=O)C3=CC=CC(F)=C3)CN4C5=CC=CC=C5N=C4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ML309 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML3091355446-05-7ML 309ML-309Isocitrate Dehydrogenase (IDH)2-hydroxyglutarateglioblastomaacute myeloid leukemiachemical probeoncologyepigeneticsisocitrate dehydrogenaseoncometaboliteInhibitorinhibitorinhibit

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