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Cat. No.: HY-P992356

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GENA-104A16

GENA-104A16 is a humanized monoclonal antibody targeting CNTN4, with multiple functions including immunostimulation, cytotoxicity and immunoregulation. By binding to CNTN4, GENA-104A16 blocks its interaction with APP, thereby restoring T cell function, inducing tumor cell death and regulating tumor-infiltrating immune cell populations. GENA-104A16 also exerts topoisomerase I inhibitory activity via the payload Exatecan (HY-13631). GENA-104A16 can be used in research related to colon cancer liver metastasis and other CNTN4-expressing solid tumors.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

GENA-104A16 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Species Reactivity

Human

IC₅₀ & Target^[1]

Topoisomerase I

All Topoisomerase Isoforms :

In Vitro

GENA-104A16 potently kills CNTN4-positive cancer cells while exhibiting low Fcγ receptor-mediated cytotoxicity, an advantageous safety feature for antibody-drug conjugates^[1].
GENA-104A16 induces CNTN4-positive tumor cell death via multiple mechanisms and enhances T cell-mediated cytotoxicity through immune checkpoint blockade^[1].
GENA-104A16 increases T cell-mediated cytotoxicity against CNTN4-expressing human osteosarcoma U2OS cells in co-culture, with this effect dependent on CNTN4 expression by the cancer cells^[2].
GENA-104A16 restores T cell proliferation, activation, cytokine release, and cytotoxic killing activity against human CNTN4-expressing cancer cell lines^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GENA-104A16 exerts anti-tumor and immune-modulatory effects in CT26/CNTN4 syngeneic mice, increasing total tumor-infiltrated immune cells 2-fold, CD4⁺ T cells 4-fold, and CD8⁺ T cells 1.5-fold while reducing Treg cell populations and restoring cytokine secretion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

152330 [NCBI]

Accession

Q8IWV2

Target

CNTN4

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Cha M Y, Yu H, Kim H, et al. Preclinical development of GENA-104 ADC, an exatecan-based novel antibody-drug conjugate targeting CNTN4, for solid tumors[J]. Cancer Research, 2026, 86(7_Supplement): 4443-4443.

[2]. Cha M Y, Yu H, Jeon B N, et al. Novel immune checkpoint inhibitor: In vivo and in vitro efficacy of anti-CNTN4 antibody, GENA-104A16 in the models with increased CNTN4 expression[J]. Cancer Research, 2023, 83(7_Supplement): 1868-1868.

[3]. Cha M Y, yu H, Jeon B N, et al. Novel immune checkpoint protein CNTN4 and the preclinical efficacy of affinity matured anti-CNTN4 antibody GENA-104A16[J]. Cancer Research, 2022, 82(12_Supplement): 2862-2862.

[4]. Cha M Y, Jeon B N, Kang H, et al. Activation of transcription factors, p65 and NFATc1, mediated by WNT5a, induces up-regulation of novel immune checkpoint CNTN4 expression[J]. Cancer Research, 2023, 83(7_Supplement): 6382-6382.

[5]. Yu H, Lee T, Kim G, et al. Immunostimulatory effects of GENA-104A16, a monoclonal anti-CNTN4 antibody, on tumor-infiltrating lymphocytes in a colon cancer liver metastasis model[J]. Cancer Research, 2025, 85(8_Supplement_1): 4790-4790.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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GENA-104A16

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

All Topoisomerase Isoforms