Bletilloside A
Based on 1 Customer Validation
Bletilloside A is a glycoside. Bletilloside A can be isolated from the tubers of Bletilla striata. Bletilloside A inhibits the expression of the TCL1A protein. When evaluated for its inhibitory activity against LPS-induced NO, Bletilloside A shows an IC50 of >70 μM. Bletilloside A exhibits anticancer activity against acute myeloid leukemia. Bletilloside A can be used in studies related to acute myeloid leukemia.
For research use only. We do not sell to patients.
- Purity : 99.88%
- CAS No.: 2292159-89-6
- Formula: C29H36O15
- Molecular Weight:624.59
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
In Vitro
Bletilloside A (1-128 μM; 48 h) inhibits the proliferation of three acute myeloid leukemia cell lines, SKNO-1, MV4-11 and HL-60[1].
Bletilloside A (30-60 μM) reduces the expression of TCL1A protein in SKNO-1 and HL-60 acute myeloid leukemia (AML) cell lines[1].
Bletilloside A (0-240 μM; 24 h) shows no cytotoxicity against RAW 264.7 macrophages, with a CC50 >240 μM[2].
Bletilloside A (1 h) exhibits an IC50 of >70 μM when evaluated for its LPS-induced NO inhibitory activity in RAW 264.7 macrophages[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
-
Cell Line:human AML cell lines SKNO-1, MV4-11, HL-60
-
Concentration:1-128 μM
-
Incubation Time:48 h
-
Result:Significantly inhibited the proliferation of SKNO-1, MV4-11, and HL-60 AML cells, with IC60 values of 29.906 μM, 36.410 μM, and 89.395 μM, respectively.
Chemical Information
-
CAS No. 2292159-89-6
-
Appearance Solid
-
Molecular Weight 624.59
-
Formula C29H36O15
-
Color White to off-white
-
SMILES
COC1=C(C=CC(/C=C/C(OCC(C=C2)=CC=C2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)=O)=C1)O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO
-
Structure Classification
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Protocols
-
RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Hong Y, et al. New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein. BMC Cancer. 2025;26(1):91. Published 2025 Dec 10. [Content Brief]
[2]. Zhao Y, et al. Chemical constituents from Bletilla striata and their NO production suppression in RAW 264.7 macrophage cells. J Asian Nat Prod Res. 2018;20(4):385-390. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bletilloside A Related Classifications
HY-N8177 Related Classifications
Powered by Bioz