Bletilloside A 

Bletilloside A is a glycoside. Bletilloside A can be isolated from the tubers of Bletilla striata. Bletilloside A inhibits the expression of the TCL1A protein. When evaluated for its inhibitory activity against LPS-induced NO, Bletilloside A shows an IC₅₀ of >70 μM. Bletilloside A exhibits anticancer activity against acute myeloid leukemia. Bletilloside A can be used in studies related to acute myeloid leukemia^[1][2].

Bletilloside A (1-128 μM; 48 h) inhibits the proliferation of three acute myeloid leukemia cell lines, SKNO-1, MV4-11 and HL-60^[1].
Bletilloside A (30-60 μM) reduces the expression of TCL1A protein in SKNO-1 and HL-60 acute myeloid leukemia (AML) cell lines^[1].
Bletilloside A (0-240 μM; 24 h) shows no cytotoxicity against RAW 264.7 macrophages, with a CC₅₀ >240 μM^[2].
Bletilloside A (1 h) exhibits an IC₅₀ of >70 μM when evaluated for its LPS-induced NO inhibitory activity in RAW 264.7 macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

624.59

C₂₉H₃₆O₁₅

2292159-89-6

Solid

White to off-white

COC1=C(C=CC(/C=C/C(OCC(C=C2)=CC=C2O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]([C@H]3O)CO)=O)=C1)O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Hong Y, et al. New drug targets for acute myeloid leukemia identified through a comprehensive analysis of the plasma protein. BMC Cancer. 2025;26(1):91. Published 2025 Dec 10.  [Content Brief]

  [2]. Zhao Y, et al. Chemical constituents from Bletilla striata and their NO production suppression in RAW 264.7 macrophage cells. J Asian Nat Prod Res. 2018;20(4):385-390.  [Content Brief]