Stigmast-5-en-3-ol
Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity.
For research use only. We do not sell to patients.
- CAS No.: 5779-62-4
- Formula: C29H50O
- Molecular Weight:414.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Biological Activity
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Caspase-9 |
Bax |
Bcl-xL |
Stigmast-5-en-3-ol (Compound DGEH21-3-2) (12.5-50 μg/mL, 24 h) shows cytotoxic effects against HL-60 and MCF-7 cells, with IC50 s of 37.82 and 45.17 μg/mL respectively[1].
Stigmast-5-en-3-ol (12.5-50 μg/mL, 24 h) induces apoptosis, increases DNA damage, increases production of Bax, Caspase-9, p53 and PARP cleavage, and decreased Bcl-xl levels in HL-60 and MCF-7 cells[1].
Stigmast-5-en-3-ol (Compound 24R) (2-10 μg/mL, 30 min) exhibits potent inhibitory activity against glucoamylase and α-amylase with IC50 s of 5.8 and 7.198 µg/mL respectively, shows high radical activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HL-60 and MCF-7 cells
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Concentration:12.5, 25, 50 μg/mL
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Incubation Time:24 h
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Result:Increased the number of apoptotic bodies and dose-dependently increased the sub-G1 apoptotic cell population, resulting in a sub-G1 apoptotic cell population of 66.30% in HL-60 cells and 60.05% in MCF-7 cells at 50 μg/ml.
Increased production of Bax, Caspase-9, and PARP cleavage, and decreased Bcl-xl levels.
Dose-dependent increased p53 expression in MCF-7 cells.
Chemical Information
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CAS No. 5779-62-4
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Molecular Weight 414.71
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Formula C29H50O
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC(CC4)O)=CC3)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Stigmast-5-en-3-ol Related Classifications
HY-N12999 Related Classifications
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