5779-62-4
Chemical Structure
Stigmast-5-en-3-ol
- CAS No.: 5779-62-4
- Formula:C29H50O
- Molecular Weight:414.71
InChIKey: KZJWDPNRJALLNS-BWRKXDIJSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CC[C@@H](CC)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC(CC4)O)=CC3)C
Biological Activity: Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity[1][2][3].
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Stigmast-5-en-3-ol | Stigmast-5-en-3-ol induces cancer cell apoptosis and inhibits proliferation by increasing the production of Bax, Caspase-9, p53, and PARP cleavage and reducing Bcl-xl expression. Stigmast-5-en-3-ol exhibits potent inhibitory activity against glucoamylase and α-amylase and possesses high antioxidant activity. Stigmast-5-en-3-ol can be used in the research of diseases such as leukemia, breast cancer, type 2 diabetes, and obesity. | |||||||||||||||||||||
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References
- [1]. Fernando IPS, et al. Apoptotic and antiproliferative effects of Stigmast-5-en-3-ol from Dendronephthya gigantea on human leukemia HL-60 and human breast cancer MCF-7 cells. Toxicol In Vitro. 2018 Oct;52:297-305. [Content Brief]
- [2]. Brinda Bolar, et al. ISOLATION AND BIOLOGICAL EVALUATION OF (24R) STIGMAST 5-EN-3-OL FROM CASSIA FISTULA BARK.
- [3]. Dina A. Ghinmy, et al. INVESTIGATION OF ANTI-OBESITY ACTIVITY OF ETHANOLIC EXTRACT OF FOENICULUM VULGARE SEEDS, IN VIVO AND IN SILICO MODELS.
