MtTMPK-IN-3
MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis.
For research use only. We do not sell to patients.
- CAS No.: 2799607-80-8
- Formula: C23H23Cl2N3O3
- Molecular Weight:460.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.12 μM (MtbTMPK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | IC50 |
6.73 μM
Compound: 25
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Cytotoxicity against human MRC-5 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis
Cytotoxicity against human MRC-5 cells assessed as reduction in cell growth measured after 3 days by resazurin dye based fluorometric analysis
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[PMID: 34450493] |
Chemical Information
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CAS No. 2799607-80-8
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Molecular Weight 460.35
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Formula C23H23Cl2N3O3
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SMILES
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC(Cl)=CC(Cl)=C4)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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