2799607-80-8
Chemical Structure
MtTMPK-IN-3
- CAS No.: 2799607-80-8
- Formula:C23H23Cl2N3O3
- Molecular Weight:460.35
IUPAC Name: 1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-4-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
InChIKey: CAJAIKQLVPYCOI-UHFFFAOYSA-N
SMILES: CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC(Cl)=CC(Cl)=C4)=CC=C3
Biological Activity: MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis[1].
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MtTMPK-IN-3 | MtTMPK-IN-3 (compound 25) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 0.12 μM. MtTMPK-IN-3 has inhibitory activity against Mtb H37Rv (MIC = 12.5 μM). MtTMPK-IN-3 exhibits certain cytotoxicity in human fibroblast cells MRC-5 (EC50 = 12.5 μM). MtTMPK-IN-3 can be used for researching tuberculosis. | |||||||||||||||||||||
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Keywords
