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STING18  (Synonyms: Stimulator of interferon genes 18)

Cat. No.: HY-158615 Purity: 98.6%
COA
SDS
Handling Instructions Technical Support

STING18 (Stimulator of interferon genes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release.

For research use only. We do not sell to patients.

STING18

STING18 Chemical Structure

CAS No. : 2706536-26-5

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STING18 Related Antibodies

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Description

STING18 (Stimulator of interferon genes 18) is a compound that inhibits STING protein by utilizing a small molecule active site dimer, with good oral exposure, slow binding kinetics, and functional inhibitory activity on STING-mediated cytokine release.

Molecular Weight

523.98

Formula

C29H27ClFNO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CC1C2=CC=C(C=C2C(N(C1C3=CC=C4OCCOC4=C3)C5=CC=C(C(C)(C)C)C(Cl)=C5)=O)F)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 10 mg/mL (19.08 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9085 mL 9.5423 mL 19.0847 mL
5 mM 0.3817 mL 1.9085 mL 3.8169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.60%

SDS (251 KB)

COA (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 1.9085 mL 9.5423 mL 19.0847 mL 47.7117 mL
5 mM 0.3817 mL 1.9085 mL 3.8169 mL 9.5423 mL
10 mM 0.1908 mL 0.9542 mL 1.9085 mL 4.7712 mL
15 mM 0.1272 mL 0.6362 mL 1.2723 mL 3.1808 mL
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STING18 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING182706536-26-5Stimulator of interferon genes 18STING 18STING-18Stimulator of interferon genes18Stimulator of interferon genes-18OthersInhibitorinhibitorinhibit

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