RDEA 806
RDEA 806 is an orally effective non-nucleoside reverse transcriptase (NNRT) inhibitor that exhibits potent in vitro inhibitory activity against wild-type HIV-1 (EC50 = 1.7 ng/mL) and NNRTI-resistant HIV-1. RDEA 806 is a prodrug of Lesinurad (HY-15258) and functions as a URAT1 inhibitor, exerting a uric acid-lowering effect. RDEA 806 rapidly reduces HIV-1 RNA viral load in vivo. RDEA 806 has a favorable biosafety profile. RDEA 806 can be used for research related to HIV-1 infection.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 878670-61-2
- Formule: C24H18BrClN4O3S
- Masse moléculaire:557.85
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 878670-61-2
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Masse moléculaire 557.85
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Formule C24H18BrClN4O3S
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SMILES
ClC(C=C(C(O)=O)C=C1)=C1NC(CSC2=NN=C(Br)N2C3=CC=C(C4CC4)C5=C3C=CC=C5)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Moyle G, et al. Phase 2a randomized controlled trial of short-term activity, safety, and pharmacokinetics of a novel nonnucleoside reverse transcriptase inhibitor, RDEA806, in HIV-1-positive, antiretroviral-naive subjects. Antimicrobial agents and chemotherapy. 2010 Aug;54(8):3170-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RDEA 806 Related Classifications
HY-105249 Related Classifications
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Keywords
- RDEA 806
- 878670-61-2
- RDEA806
- RDEA-806
- HIV
- Reverse Transcriptase
- URAT1
- Human immunodeficiency virus
- Urate transporter 1
- SLC22A12
- HIV-1 RNA viral load
- HIV-1-infected subjects
- HIV-1 infection
- oral agent
- NNRTI-resistant mutants
- NNRTI-resistant
- NNRTI
- wild-type
- antiretroviral-na?ve
- HIV-1 reverse transcriptase
- Inhibitor
- inhibitor
- inhibit