2. Anti-infection
  3. Bacterial
  4. NOSO-502

NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties.

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NOSO-502 Chemical Structure

NOSO-502 Chemical Structure

CAS No. : 1894081-09-4

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NOSO-502 Related Antibodies

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Description

NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties[1].

In Vitro

NOSO-502 (16 µg/mL and 32 µg/mL; 24 h) causes E.coli ATCC 25922 and K. pneumoniae ATCC 43816 strains develop resistance to NOSO-502[1].
NOSO-502 (100 µM) decreases the activity of HRPTEpiC cells, but insignificantly increases the expression of heat shock protein 27 (HSP27) and kidney injury molecule 1 (KIM-1)[1].
Antibacterial in vitro activities of NOSO-502[1]

Citrobacter freundii DSM 30039 Citrobacter kozeri DSM 4595 Enterobacter aerogenes DSM 30053 Enterobacter cloacae DSM 14563 Escherichia coli ATCC 25922
MIC (µg/mL) 2 2 2 2 4
Klebsiella pneumoniae ATCC 43816 Serratia marcescens DSM 17174 Stenotrophomonas maltophilia ATCC 13637 Staphylococcus aureus ATCC 29213 Staphylococcus epidermidis ATCC 12228
MIC (µg/mL) 1 4 16 1 0.25

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NOSO-502 Related Antibodies
In Vivo

NOSO-502 (1.3-40 mg/kg; s.c.; single dose) shows antibacterial activity in NMRI mice infected E. coli EN122[1].
NOSO-502 (4-24 mg/kg; s.c.; single dose) shows protective effect in C3H/HeN mice infected E. coli UTI89[1].
NOSO-502 (2-80 mg/kg; s.c.; single dose) shows protective effect in CD-1/ICR mice infected K. pneumoniae NCTC 13442[1].
Pharmacokinetic (PK) parameters of NOSO-502[1]

Species Route Dose (mg/kg) Cmax (mg/L) AUC0-Tlast (mg/L•h) Vd (L/kg) T1/2 (min) Clearance (L/h/kg)
Mouse Intravenous injection 30 23.46 8.88 0.66 25 1.13
Rat Intravenous injection 15 40.70 7.99 0.94 90 1.92

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NMRI mice infected E. coli EN122[1].
Dosage: 1.3, 2.5, 5, 10, 20, and 40 mg/kg.
Administration: Subcutaneous injection; single dose.
Result: Showed anti-infective effect.
Animal Model: Female C3H/HeN mice infected E. coli UTI89[1].
Dosage: 4, 12 and 24 mg/kg.
Administration: Subcutaneous injection; single dose.
Result: Significantly attenuated E. coli UTI89 damage to urine, bladder, kidneys, and improved survival rates.
Animal Model: Male CD-1/ICR mice infected K. pneumoniae NCTC 13442[1].
Dosage: 2, 6, 20 and 80 mg/kg.
Administration: Subcutaneous injection; single dose.
Result: Significantly improved lung tissue damage.
Molecular Weight

1078.24

Formula

C47H80FN17O11
CAS No.
SMILES

N=C(N)NCC/C=C(C(O)=O)\NC([C@H](CCCCN)NC([C@H](CC1=CC=CC=C1F)NC([C@H]2N(CCC2)C([C@@H](CCCN)NC(CNC([C@H](CCN)NC([C@H]([C@@H](O)CN)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NOSO-502 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOSO-5021894081-09-4NOSO502NOSO 502BacterialCD-1/ICR miceC3H/HeN miceNMRI miceHRPTEpiC cellsHSP27KIM-1Inhibitorinhibitorinhibit

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