NOSO-502
NOSO-502 is an inhibitor of bacterial translation. NOSO-502 exhibits inhibitory activity against Enterobacteriaceae. NOSO-502 has good safety and antibacterial properties.
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- No. CAS: 1894081-09-4
- Fòrmula: C47H80FN17O11
- Peso molecular:1078.24
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Actividad biológica
Descripciòn
In Vitro
NOSO-502 (16 µg/mL and 32 µg/mL; 24 h) causes E.coli ATCC 25922 and K. pneumoniae ATCC 43816 strains develop resistance to NOSO-502[1].
NOSO-502 (100 µM) decreases the activity of HRPTEpiC cells, but insignificantly increases the expression of heat shock protein 27 (HSP27) and kidney injury molecule 1 (KIM-1)[1].
Antibacterial in vitro activities of NOSO-502[1]
| Citrobacter freundii DSM 30039 | Citrobacter kozeri DSM 4595 | Enterobacter aerogenes DSM 30053 | Enterobacter cloacae DSM 14563 | Escherichia coli ATCC 25922 | |||||||||||||||||||||||||||||||
| MIC (µg/mL) | 2 | 2 | 2 | 2 | 4 | ||||||||||||||||||||||||||||||
| Klebsiella pneumoniae ATCC 43816 | Serratia marcescens DSM 17174 | Stenotrophomonas maltophilia ATCC 13637 | Staphylococcus aureus ATCC 29213 | Staphylococcus epidermidis ATCC 12228 | |
| MIC (µg/mL) | 1 | 4 | 16 | 1 | 0.25 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
NOSO-502 (4-24 mg/kg; s.c.; single dose) shows protective effect in C3H/HeN mice infected E. coli UTI89[1].
NOSO-502 (2-80 mg/kg; s.c.; single dose) shows protective effect in CD-1/ICR mice infected K. pneumoniae NCTC 13442[1].
Pharmacokinetic (PK) parameters of NOSO-502[1]
| Species | Route | Dose (mg/kg) | Cmax (mg/L) | AUC0-Tlast (mg/L•h) | Vd (L/kg) | T1/2 (min) | Clearance (L/h/kg) |
| Mouse | Intravenous injection | 30 | 23.46 | 8.88 | 0.66 | 25 | 1.13 |
| Rat | Intravenous injection | 15 | 40.70 | 7.99 | 0.94 | 90 | 1.92 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NMRI mice infected E. coli EN122[1].
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Dosage:1.3, 2.5, 5, 10, 20, and 40 mg/kg.
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Administration:Subcutaneous injection; single dose.
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Result:Showed anti-infective effect.
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Animal Model:Female C3H/HeN mice infected E. coli UTI89[1].
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Dosage:4, 12 and 24 mg/kg.
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Administration:Subcutaneous injection; single dose.
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Result:Significantly attenuated E. coli UTI89 damage to urine, bladder, kidneys, and improved survival rates.
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Animal Model:Male CD-1/ICR mice infected K. pneumoniae NCTC 13442[1].
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Dosage:2, 6, 20 and 80 mg/kg.
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Administration:Subcutaneous injection; single dose.
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Result:Significantly improved lung tissue damage.
Chemical Information
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No. CAS 1894081-09-4
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Peso molecular 1078.24
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Fòrmula C47H80FN17O11
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SMILES
N=C(N)NCC/C=C(C(O)=O)\NC([C@H](CCCCN)NC([C@H](CC1=CC=CC=C1F)NC([C@H]2N(CCC2)C([C@@H](CCCN)NC(CNC([C@H](CCN)NC([C@H]([C@@H](O)CN)NC([C@@H](N)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NOSO-502 Related Classifications
HY-123922 Related Classifications
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