1. Anti-infection
  2. Bacterial
  3. ACHN-975

ACHN-975 

Cat. No.: HY-19936
Handling Instructions

ACHN-975 is a selective LpxC inhibitor, exhibiting a subnanomolar LpxC inhibitory activity and low MIC values (≤1 μg/mL) against a wide range of Gram-negative bacteria. LpxC is highly conserved in Gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase.

For research use only. We do not sell to patients.

ACHN-975 Chemical Structure

ACHN-975 Chemical Structure

CAS No. : 1410809-36-7

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Description

ACHN-975 is a selective LpxC inhibitor, exhibiting a subnanomolar LpxC inhibitory activity and low MIC values (≤1 μg/mL) against a wide range of Gram-negative bacteria. LpxC is highly conserved in Gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis[1]. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase[1].

IC50 & Target

LpxC[1]

In Vitro

ACHN-975 is against Enterobacteriaceae spp with an IC50 of 0.02 nM[1].
ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively[1].

Molecular Weight

369.41

Formula

C₂₀H₂₃N₃O₄

CAS No.

1410809-36-7

SMILES

O=C(N[[email protected]](C(NO)=O)C(C)(N)C)C1=CC=C(C#CC#C[[email protected]]2[[email protected]](CO)C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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ACHN-975
Cat. No.:
HY-19936
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