2. Anti-infection
  3. Bacterial
  4. ACHN-975 TFA

ACHN-975 TFA is a selective LpxC inhibitor and exhibits a subnanomolar LpxC inhibitory activity. ACHN-975 TFA is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL).

For research use only. We do not sell to patients.

ACHN-975 TFA Chemical Structure

ACHN-975 TFA Chemical Structure

CAS No. : 1410809-37-8

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 404 In-stock
Solution
10 mM * 1 mL in DMSO USD 404 In-stock
Solid
1 mg USD 160 In-stock
5 mg USD 380 In-stock
10 mg USD 600 In-stock
25 mg USD 1200 In-stock
50 mg USD 1900 In-stock
100 mg USD 2850 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of ACHN-975 TFA:

ACHN-975 TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE ACHN-975 TFA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ACHN-975 TFA is a selective LpxC inhibitor and exhibits a subnanomolar LpxC inhibitory activity. ACHN-975 TFA is against a wide range of gram-negative bacterias with low MIC values (≤1 μg/mL)[1].

IC50 & Target

IC50: LpxC[1]
In Vitro

ACHN-975 is against Enterobacteriaceae spp with an IC50 of 0.02 nM[1].
ACHN-975 is against Enterobacteriaceae spp, Pa, and Ab with MIC90 values of 1, 0.5, and >64 μg/mL, respectively[1].
ACHN-975 is potently against the P. aeruginosa isolates tested, inhibiting 100% of the isolates at an MIC of ≤2 μg/ml. It against Pseudomonas aeruginosa with an MIC50 and MIC90 of 0.06 and 0.25 μg/ml, respectively[2].
ACHN-975 is against six P. aeruginosa isolates, it against P. aeruginosa APAE1064, APAE1232, and APAE1064 isolates with MIC values of 0.12, 0.06 and 0.06  μg/ml, respectively[2].
LpxC is highly conserved in gram-negative bacteria and catalyzes the first committed step of lipid A biosynthesis. LpxC is the bacterial enzyme Zinc-dependent metalloamidase UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ACHN-975 TFA Related Antibodies
In Vivo

ACHN-975 TFA (intraperitoneal administration; 5-30 mg/kg; single dose) leads to a steady reduction in bacterial titers in the first 4 h following treatment for all dosing groups. The sampling shows that the level of free drug in this model drops below the ACHN-975 MIC for this isolate (0.25 μg/ml) by 2 h after treatment with the 10 mg/kg dose and by 4 h after treatment with the 30 mg/kg dose[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neutropenic mouse thigh model with P. aeruginosa ATCC 27853[2]
Dosage: 5-30 mg/kg
Administration: Intraperitoneal administration; single dose
Result: Had a bactericidal activity and was against the P. aeruginosa ATCC27853 strain in vivo.
Clinical Trial
Molecular Weight

483.44

Formula

C22H24F3N3O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N[C@H](C(NO)=O)C(C)(N)C)C1=CC=C(C#CC#C[C@H]2[C@H](CO)C2)C=C1.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (206.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0685 mL 10.3425 mL 20.6851 mL
5 mM 0.4137 mL 2.0685 mL 4.1370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.57%

COA (248 KB) HNMR (269 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0685 mL 10.3425 mL 20.6851 mL 51.7127 mL
5 mM 0.4137 mL 2.0685 mL 4.1370 mL 10.3425 mL
10 mM 0.2069 mL 1.0343 mL 2.0685 mL 5.1713 mL
15 mM 0.1379 mL 0.6895 mL 1.3790 mL 3.4475 mL
20 mM 0.1034 mL 0.5171 mL 1.0343 mL 2.5856 mL
25 mM 0.0827 mL 0.4137 mL 0.8274 mL 2.0685 mL
30 mM 0.0690 mL 0.3448 mL 0.6895 mL 1.7238 mL
40 mM 0.0517 mL 0.2586 mL 0.5171 mL 1.2928 mL
50 mM 0.0414 mL 0.2069 mL 0.4137 mL 1.0343 mL
60 mM 0.0345 mL 0.1724 mL 0.3448 mL 0.8619 mL
80 mM 0.0259 mL 0.1293 mL 0.2586 mL 0.6464 mL
100 mM 0.0207 mL 0.1034 mL 0.2069 mL 0.5171 mL
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ACHN-975 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACHN-9751410809-37-8ACHN975ACHN 975BacterialP. aeruginosainfectionEnterobacteriaceaeAPAE1064APAE1232LpxCInhibitorinhibitorinhibit

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