LINS05414
LINS05414 is a histamine H3 receptor ligand with antiCholinesterase and metal chelating activities. LINS05414 exhibits inhibitory activity against acetylcholinesterase (pIC50 = 4.03) and butyrylcholinesterase (pIC50 = 3.83), with a pKi of 6.37 for human histamine H3 receptors. LINS05414 chelates copper ions, ferrous ions and ferric ions. LINS05414 regulates the release of neurotransmitters. LINS05414 can be used in the research of neurodegenerative diseases.
For research use only. We do not sell to patients.
- Formula: C22H25N5O
- Molecular Weight:375.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Histamine Receptor Isoforms
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Biological Activity
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H3 receptor |
AChE |
BChE |
LINS05414 (90 min at 25 °C) binds to histamine H3 receptors in HEK-293-hH3R cell membranes with a pKi of 6.37 ± 0.13[1].
LINS05414 (10 min at 37 °C) inhibits Electrophorus electricus acetylcholinesterase with a pIC50 of 4.03 ± 0.12[1].
LINS05414 (50 μM) chelates Fe2+, Fe3+, and Cu2+ ions, as evidenced by bathochromic shifts of its absorption bands in UV-Vis spectrophotometry[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 375.47
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Formula C22H25N5O
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SMILES
O=C(C1=NC=CC2=C1C=CC=C2)NCCCN3CCN(C4=CC=NC=C4)CC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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