2. Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Cholinesterase (ChE) Histamine Receptor
  4. LINS05414

LINS05414 is a histamine H3 receptor ligand with antiCholinesterase and metal chelating activities. LINS05414 exhibits inhibitory activity against acetylcholinesterase (pIC50 = 4.03) and butyrylcholinesterase (pIC50 = 3.83), with a pKi of 6.37 for human histamine H3 receptors. LINS05414 chelates copper ions, ferrous ions and ferric ions. LINS05414 regulates the release of neurotransmitters. LINS05414 can be used in the research of neurodegenerative diseases.

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LINS05414

LINS05414 Chemical Structure

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LINS05414 Related Antibodies

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AChE BChE

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H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

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Description

LINS05414 is a histamine H3 receptor ligand with antiCholinesterase and metal chelating activities. LINS05414 exhibits inhibitory activity against acetylcholinesterase (pIC50 = 4.03) and butyrylcholinesterase (pIC50 = 3.83), with a pKi of 6.37 for human histamine H3 receptors. LINS05414 chelates copper ions, ferrous ions and ferric ions. LINS05414 regulates the release of neurotransmitters. LINS05414 can be used in the research of neurodegenerative diseases[1].

IC50 & Target[1]

H3 receptor

 

AChE

 

BChE

 

In Vitro

LINS05414 (90 min at 25 °C) binds to histamine H3 receptors in HEK-293-hH3R cell membranes with a pKi of 6.37 ± 0.13[1].
LINS05414 (10 min at 37 °C) inhibits Electrophorus electricus acetylcholinesterase with a pIC50 of 4.03 ± 0.12[1].
LINS05414 (50 μM) chelates Fe2+, Fe3+, and Cu2+ ions, as evidenced by bathochromic shifts of its absorption bands in UV-Vis spectrophotometry[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LINS05414 Related Antibodies
Molecular Weight

375.47

Formula

C22H25N5O
SMILES

O=C(C1=NC=CC2=C1C=CC=C2)NCCCN3CCN(C4=CC=NC=C4)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LINS05414 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LINS05414LINS 05414LINS-05414Cholinesterase (ChE)Histamine Receptorhistamine H3 receptor ligandantiCholinesterasemetal chelating activitiesHEK-293-hH3R cell
Inhibitorinhibitorinhibit

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