SIQ17
SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research
For research use only. We do not sell to patients.
- CAS No.: 2151881-74-0
- Formula: C32H27NO2S
- Molecular Weight:489.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Biological Activity
Description
In Vitro
SIQ17 (10 μM, 72 hours) has a stronger inhibits on cell viability of A431 cells compare to A549 cells[1].
SIQ17 (0-100 μM, 24 hours) has thecytotoxic effects, with IC50s of 32.98 μM and 19.17μM for A549 cells and A431 cells respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:A549, A431
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Concentration:10 μM
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Incubation Time:72 hours
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Result:Had a stronger inhibits on cell viability of A431 cells compare to A549 cells
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Cell Line:A549, A431, Vero cell lines
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Concentration:0-100 μM
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Incubation Time:24 hours
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Result:Had thecytotoxic effects, with IC50s of 32.98μM and 19.17μM for A549 cells and A431 cells respectively.
Chemical Information
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CAS No. 2151881-74-0
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Molecular Weight 489.63
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Formula C32H27NO2S
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SMILES
O=S(C(C1=C2C=CC=C1)=C3C2=C(C4=CC=C(C)C=C4C)N(C)C5=C3C=CC=C5)(C6=CC=C(C)C=C6)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIQ17 Related Classifications
HY-149846 Related Classifications
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