2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. SIQ17

SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research

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SIQ17 Chemical Structure

SIQ17 Chemical Structure

CAS No. : 2151881-74-0

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SIQ17 Related Antibodies

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Description

SIQ17 is an EGFR inhibitor that inhibits its activity by occupying the ATP-binding site, with IC50 of 0.62 nM. SIQ17 shows more effective EGFR-TK inhibitory activity compared to the known inhibitor Erlotinib (HY-50896) (IC50 of ∼20 nM). SIQ17 can be used for cancer research[1]

In Vitro

SIQ17 (10 μM, 72 hours) has a stronger inhibits on cell viability of A431 cells compare to A549 cells[1].
SIQ17 (0-100 μM, 24 hours) has thecytotoxic effects, with IC50s of 32.98 μM and 19.17μM for A549 cells and A431 cells respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIQ17 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549, A431
Concentration: 10 μM
Incubation Time: 72 hours
Result: Had a stronger inhibits on cell viability of A431 cells compare to A549 cells

Cell Cytotoxicity Assay[1]

Cell Line: A549, A431, Vero cell lines
Concentration: 0-100 μM
Incubation Time: 24 hours
Result: Had thecytotoxic effects, with IC50s of 32.98μM and 19.17μM for A549 cells and A431 cells respectively.
Molecular Weight

489.63

Formula

C32H27NO2S
CAS No.
SMILES

O=S(C(C1=C2C=CC=C1)=C3C2=C(C4=CC=C(C)C=C4C)N(C)C5=C3C=CC=C5)(C6=CC=C(C)C=C6)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIQ17 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIQ172151881-74-0SIQ 17SIQ-17EGFREpidermal growth factor receptorErbB-1HER1A549A431anti-tumoranticancerInhibitorinhibitorinhibit

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