Topo II/HDAC-IN-1

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Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-1 (8d) induces apoptosis.

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Topo II/HDAC-IN-1 Chemical Structure

CAS No. : 2922269-18-7

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Biological Activity
Purity & Documentation
References
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Description

Topo II/HDAC-IN-1 (7d) exhibits excellent dual inhibitory activities against Topo II and HDAC. Topo II/HDAC-IN-1 (8d) induces apoptosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	1143 μM Compound: 7d	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 36996717]
MGC-803	IC₅₀	9.59 μM Compound: 7d	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 36996717]
U-937	IC₅₀	28.46 μM Compound: 7d	Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay Antiproliferative activity against human U-937 cells assessed as reduction in cell viability measured for 48 hrs by MTT assay	[PMID: 36996717]

In Vitro

Topo II/HDAC-IN-1 (7d) has the best inhibitory activity against MGC-803 and MCF-7, with IC₅₀ values of 9.59 μM and 13.43 μM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

332.38

Formula

C₁₅H₁₆N₄O₃S

CAS No.

2922269-18-7

SMILES

O=C(NO)CCCCSC1=NC2=C(C(N1)=O)NC3=C2C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mengmiao Zhao, et al. Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs. Eur J Med Chem. 2023 Apr 5;252:115303. [Content Brief]

Topo II/HDAC-IN-1 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topo II/HDAC-IN-12922269-18-7TopoisomeraseHDACApoptosisHistone deacetylasesTopo IIapoptosisInhibitorinhibitorinhibit

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