PROTAC VEGFR-2 degrader-2
PROTAC VEGFR-2 degrader-2 is a VEGFR-2 (KDR) PROTAC degrader with weak inhibitory activity against VEGFR-2 (IC50 > 1 μM). It is applicable to the research of cancer-related pathological angiogenesis.
(Pink: KDR ligand (HY-50751); Blue: VHL ligand (HY-125845); Black: linker (HY-Y1139)).
For research use only. We do not sell to patients.
- CAS No.: 2353417-85-1
- Formula: C50H56FN9O6S
- Molecular Weight:930.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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VEGFR2 > 1 μM μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| EA.hy 926 | IC50 |
133.248 μM
Compound: PROTAC-4
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Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
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[PMID: 32750566] |
PROTAC VEGFR-2 degrader-2 (PROTAC-4) (24 h) inhibits proliferation of EA.hy926 human umbilical vein endothelial cells with an IC50 of 133.248 μM[1].
PROTAC VEGFR-2 degrader-2 (100 μM) exhibits no significant cytotoxicity against HEK293 human embryonic kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2353417-85-1
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Molecular Weight 930.10
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Formula C50H56FN9O6S
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SMILES
CC1=CC=C(C(NC(NC2=CC=C(C=C2)C3=CC=CC4=C3C(N)=NN4C(CCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O)=C1)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC VEGFR-2 degrader-2 Related Classifications
HY-146369 Related Classifications
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