PROTAC VEGFR-2 degrader-2
Based on 1 Customer Validation
PROTAC VEGFR-2 degrader-2 is a VEGFR-2 (KDR) PROTAC degrader with weak inhibitory activity against VEGFR-2 (IC50 > 1 μM). It is applicable to the research of cancer-related pathological angiogenesis.
(Pink: KDR ligand (HY-50751); Blue: VHL ligand (HY-125845); Black: linker (HY-Y1139)).
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 2353417-85-1
- Formula: C50H56FN9O6S
- Molecular Weight:930.10
-
Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
VEGFR2 > 1 μM μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| EA.hy 926 | IC50 |
133.248 μM
Compound: PROTAC-4
|
Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
Antiangiogenic activity in human EA.hy 926 cells measured after 24 hrs by MTT assay
|
[PMID: 32750566] |
PROTAC VEGFR-2 degrader-2 (PROTAC-4) (24 h) inhibits proliferation of EA.hy926 human umbilical vein endothelial cells with an IC50 of 133.248 μM[1].
PROTAC VEGFR-2 degrader-2 (100 μM) exhibits no significant cytotoxicity against HEK293 human embryonic kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2353417-85-1
-
Appearance Solid
-
Molecular Weight 930.10
-
Formula C50H56FN9O6S
-
Color White to off-white
-
SMILES
CC1=CC=C(C(NC(NC2=CC=C(C=C2)C3=CC=CC4=C3C(N)=NN4C(CCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O)=O)=C1)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (107.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0752 mL | 5.3758 mL | 10.7515 mL | 26.8788 mL |
| 5 mM | 0.2150 mL | 1.0752 mL | 2.1503 mL | 5.3758 mL | |
| 10 mM | 0.1075 mL | 0.5376 mL | 1.0752 mL | 2.6879 mL | |
| 15 mM | 0.0717 mL | 0.3584 mL | 0.7168 mL | 1.7919 mL | |
| 20 mM | 0.0538 mL | 0.2688 mL | 0.5376 mL | 1.3439 mL | |
| 25 mM | 0.0430 mL | 0.2150 mL | 0.4301 mL | 1.0752 mL | |
| 30 mM | 0.0358 mL | 0.1792 mL | 0.3584 mL | 0.8960 mL | |
| 40 mM | 0.0269 mL | 0.1344 mL | 0.2688 mL | 0.6720 mL | |
| 50 mM | 0.0215 mL | 0.1075 mL | 0.2150 mL | 0.5376 mL | |
| 60 mM | 0.0179 mL | 0.0896 mL | 0.1792 mL | 0.4480 mL | |
| 80 mM | 0.0134 mL | 0.0672 mL | 0.1344 mL | 0.3360 mL | |
| 100 mM | 0.0108 mL | 0.0538 mL | 0.1075 mL | 0.2688 mL |
PROTAC VEGFR-2 degrader-2 Related Classifications
HY-146369 Related Classifications
Powered by Bioz