ZX-J-19L
ZX-J-19L is a CyPJ inhibitor with inhibitory activity against a variety of tumor cell lines. ZX-J-19L inhibits the growth of human liver cancer cells, human breast cancer cells, ovarian cancer cells and prostate cancer cells in vitro. ZX-J-19L can be used for tumor research.
For research use only. We do not sell to patients.
- CAS No.: 1346754-06-0
- Formula: C24H21N3O
- Molecular Weight:367.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Cyclophilin Isoforms
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Biological Activity
ZX-J-19L (1.0-250 µM; 48 h) inhibits the proliferation of human hepatocellular carcinoma SK-HEP1 and QGY cells[1].
ZX-J-19L (20 µM; 48 h) inhibits the growth of human breast cancer (HCC1954, BT474, MDA-MB468), ovarian cancer (SKOV3) and prostate cancer (PC3, LNCaP) cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human hepatocellular carcinoma (HCC) SK-HEP1/QGY cells
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Concentration:1.0, 5.0, 10, 50, 250 µM
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Incubation Time:48 h
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Result:Inhibited SK-HEP1 cell growth with an IC50 of 3.512 µM.
Inhibited QGY cell growth with an IC50 of 21.353 µM.
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Cell Line:human breast cancer HCC1954, BT474, MDA-MB468 cells; human ovarian cancer SKOV3 cells; human prostate cancer PC3, LNCaP cells
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Concentration:20 µM
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Incubation Time:48 h
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Result:Inhibited HCC1954 cell growth by 91.258%.
Inhibited BT474 cell growth by 90.963%.
Inhibited MDA-MB468 cell growth by 90.849%.
Inhibited SKOV3 cell growth by 90.919%.
Inhibited PC3 cell growth by 91.039%.
Inhibited LNCaP cell growth by 91.038%.
Chemical Information
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CAS No. 1346754-06-0
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Molecular Weight 367.44
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Formula C24H21N3O
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SMILES
O=C(CCC)NC1=CC=C2N=C(C(C3=CC=CC=C3)=NC2=C1)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)