1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. c-Met/HGFR
    Apoptosis
  3. c-Met-IN-10

c-Met-IN-10 

Cat. No.: HY-146274
Handling Instructions

c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer.

For research use only. We do not sell to patients.

c-Met-IN-10 Chemical Structure

c-Met-IN-10 Chemical Structure

CAS No. : 2415291-03-9

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Description

c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].

IC50 & Target[1]

c-Met

16 nM (IC50)

Molecular Weight

516.48

Formula

C26H21FN6O5

CAS No.
SMILES

O=C(C1=NN(C(N(C1=O)C)=O)C2=CC=CC=C2)NC3=CC=C(C(F)=C3)OC4=CC(NC(C5CC5)=O)=NC=C4

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c-Met-IN-10
Cat. No.:
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