2415291-03-9
Chemical Structure
c-Met-IN-10
- CAS No.: 2415291-03-9
- Formula:C26H21FN6O5
- Molecular Weight:516.48
IUPAC Name: N-(4-((2-(cyclopropanecarboxamido)pyridin-4-yl)oxy)-3-fluorophenyl)-4-methyl-3,5-dioxo-2-phenyl-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxamide
InChIKey: WAJMNPGYTYIUHZ-UHFFFAOYSA-N
SMILES: O=C(C1=NN(C(N(C1=O)C)=O)C2=CC=CC=C2)NC3=CC=C(C(F)=C3)OC4=CC(NC(C5CC5)=O)=NC=C4
Biological Activity: c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].
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c-Met-IN-10 | c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer. | |||||||||||||||||||||
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Keywords
