3,9-Dihydroeucomin

Cat. No.: HY-137011 Purity: 97.0%: Data Sheet
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3,9-Dihydroeucomin (compound 12) is a natural homoisoflavonoid compound with less COX-2 inhibitory activitys.

For research use only. We do not sell to patients.

3,9-Dihydroeucomin Chemical Structure

CAS No. : 887375-68-0

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

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COX COX-1 COX-2 COX-3

Biological Activity
Purity & Documentation
References
Customer Review

Description

3,9-Dihydroeucomin (compound 12) is a natural homoisoflavonoid compound with less COX-2 inhibitory activitys^[1].

IC₅₀ & Target^[1]

COX-2

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 100 μM Compound: 9	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 19689125]
B16-BL6	IC₅₀	64.3 μM Compound: 9	Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay Cytotoxicity against mouse B16-BL6 cells after 72 hrs by MTT assay	[PMID: 19689125]
HT-1080	IC₅₀	> 100 μM Compound: 9	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	[PMID: 19689125]
HUVEC	GI₅₀	> 100 μM Compound: 5	Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay Antiproliferative activity against HUVEC assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay	[PMID: 30951308]
HeLa	IC₅₀	> 100 μM Compound: 9	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	[PMID: 19689125]
PANC-1	IC₅₀	> 100 μM Compound: 9	Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay	[PMID: 19689125]
Y79	GI₅₀	> 100 μM Compound: 5	Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay Cytotoxicity against human Y79 cells assessed as reduction in cell number incubated for 44 hrs by alamar blue based fluorescence assay	[PMID: 30951308]

Molecular Weight

300.31

Formula

C₁₇H₁₆O₅

CAS No.

887375-68-0

Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@H](CC2=CC=C(OC)C=C2)COC3=CC(O)=CC(O)=C13

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Purity: 97.0%

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Data Sheet (265 KB) SDS (393 KB)

COA (245 KB)

Handling Instructions (2659 KB)

References

[1]. Waller CP, et al. COX-2 inhibitory activity of homoisoflavanones and xanthones from the bulbs of the Southern African Ledebouria socialis and Ledebouria ovatifolia (Hyacinthaceae: Hyacinthoideae). Phytochemistry. 2013 Nov;95:284-90. [Content Brief]